Comprehensive studies of pharmacokinetics and biodistribution of indocyanine green and liposomal indocyanine green by multispectral optoacoustic tomography
文献类型：期刊论文
| 作者 | Song,Wantong; Tang,Zhaohui; Zhang,Dawei; Burton,Neal; Dirssen,Wouter; Chen,Xuesi |
| 刊名 | rsc advances
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:5页码:3807-3813 |
| 关键词 | COMPUTED-TOMOGRAPHY MICELLES CANCER FLUORESCENCE MICROSCOPY CISPLATIN CARRIERS PROBES TUMORS DEEP |
| 通讯作者 | tang,zh |
| 英文摘要 | real-time and continuous monitoring of systemically administered agents is an important task in pharmaceutical development. herein, we performed a real-time continuous study of the pharmacokinetics and biodistribution of indocyanine green (icg) and liposomal indocyanine green (lipo-icg) in vivo by multispectral optoacoustic tomography (msot). by comparing the blood clearance and uptake behavior of these two icg formulations in liver, spleen, kidney and tumor, we showed that lipo-icg prolonged the retention time of icg in blood, and resulted in enhanced accumulation and retention in liver, spleen, and tumor. the results obtained from the msot test provided a comprehensive and continuous view of the metabolic behavior of the injected agents in different formulations. the results may also be helpful for understanding this new imaging technique. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-31 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/67812]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Song,Wantong,Tang,Zhaohui,Zhang,Dawei,et al. Comprehensive studies of pharmacokinetics and biodistribution of indocyanine green and liposomal indocyanine green by multispectral optoacoustic tomography[J]. rsc advances,2015,5(5):3807-3813. |
| APA | Song,Wantong,Tang,Zhaohui,Zhang,Dawei,Burton,Neal,Dirssen,Wouter,&Chen,Xuesi.(2015).Comprehensive studies of pharmacokinetics and biodistribution of indocyanine green and liposomal indocyanine green by multispectral optoacoustic tomography.rsc advances,5(5),3807-3813. |
| MLA | Song,Wantong,et al."Comprehensive studies of pharmacokinetics and biodistribution of indocyanine green and liposomal indocyanine green by multispectral optoacoustic tomography".rsc advances 5.5(2015):3807-3813. |
入库方式： OAI收割
来源：长春应用化学研究所
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