cRGD targeted and charge conversion-controlled release micelles for doxorubicin delivery
文献类型：期刊论文
| 作者 | Guan,Xingang; Hu,Xiuli; Li,Zhizhong; Zhang,Hong; Xie,Zhigang |
| 刊名 | rsc advances
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:29页码:22957-22964 |
| 关键词 | ENHANCED ANTITUMOR EFFICACY DRUG-DELIVERY CANCER-THERAPY TRIBLOCK COPOLYMER POLYMERIC MICELLES TUMOR VASCULATURE NANOPARTICLES THERAPEUTICS CISPLATIN PRODRUG |
| 通讯作者 | xie,zg |
| 英文摘要 | efficiently and selectively delivering chemotherapeutic agents to tumours still remains a challenge for the development of nanocarriers. in this study, polymer micelles based on crgd targeting and ph-sensitive surface charge-switching were successfully prepared and used for doxorubicin (dox) delivery. this nanoscale polymeric micelle indicated a high drug encapsulation efficiency of 90% and slightly negative charge. drug release experiments showed a ph-enhanced release profile in pbs, which resulted from surface charge-switching by imidazole. confocal laser scanning microscopy and flow cytometry experiments indicated that combining the capability of an rgd target and ph-sensitive charge-switching significantly enhanced the cellular uptake of b16f10 cells overexpressing alpha(v)beta(3) integrins. an mtt assay also showed that our hybrid rgd-decorated micelles were much more cytotoxic to b16f10 cells than undecorated micelles. these results suggest the potential application of a crgd target and ph-sensitive surface charge-switching polymeric micelles in the treatment of alpha(v)beta(3) integrin-overexpressing cancers. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350643700080 |
| 公开日期 | 2016-05-31 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/67824]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Guan,Xingang,Hu,Xiuli,Li,Zhizhong,et al. cRGD targeted and charge conversion-controlled release micelles for doxorubicin delivery[J]. rsc advances,2015,5(29):22957-22964. |
| APA | Guan,Xingang,Hu,Xiuli,Li,Zhizhong,Zhang,Hong,&Xie,Zhigang.(2015).cRGD targeted and charge conversion-controlled release micelles for doxorubicin delivery.rsc advances,5(29),22957-22964. |
| MLA | Guan,Xingang,et al."cRGD targeted and charge conversion-controlled release micelles for doxorubicin delivery".rsc advances 5.29(2015):22957-22964. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。