In situ crosslinkable hydrogels formed from modified starch and O-carboxymethyl chitosan
文献类型：期刊论文
| 作者 | Li,Yangling; Tan,Ying; Xu,Kun; Lu,Cuige; Liang,Xuechen; Wang,Pixin |
| 刊名 | rsc advances
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:38页码:30303-30309 |
| 关键词 | DRUG-DELIVERY SYSTEMS ACUTE DOXORUBICIN TOXICITY CANCER-THERAPY BIODEGRADABLE HYDROGELS ALPHA-CYCLODEXTRIN POLYMERIC MICELLES CONTROLLED-RELEASE ONCOLOGY-GROUP DACTINOMYCIN DAUNORUBICIN |
| 通讯作者 | tan,y |
| 英文摘要 | an in situ hydrogel based on oxidation cholesterol starch (ocs) and o-carboxymethyl chitosan (cmct) that is completely devoid of potentially cytotoxic small molecule cross-linkers and does not require complex manoeuvres or catalysis has been formulated and characterized. the network structure was created by schiff base formation. the mechanical properties, internal morphology and swelling ability of the injectable hydrogel were examined. rheological measurements demonstrated that increasing the concentration of the monomer improved the storage modulus. sem showed that the hydrogel possessed a well-defined porous structure. in addition, the schiff base reaction was acid sensitive. under acid conditions, the hydrogel could hydrolyse quickly compared with high ph conditions. doxorubicin (dox) was used as a model drug to investigate the control and release properties of the hydrogel. the cytotoxic potential of the hydrogel was determined using an in vitro viability assay with l929 cells as a model and the results revealed that the hydrogel was non-cytotoxic. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-31 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/67831]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li,Yangling,Tan,Ying,Xu,Kun,et al. In situ crosslinkable hydrogels formed from modified starch and O-carboxymethyl chitosan[J]. rsc advances,2015,5(38):30303-30309. |
| APA | Li,Yangling,Tan,Ying,Xu,Kun,Lu,Cuige,Liang,Xuechen,&Wang,Pixin.(2015).In situ crosslinkable hydrogels formed from modified starch and O-carboxymethyl chitosan.rsc advances,5(38),30303-30309. |
| MLA | Li,Yangling,et al."In situ crosslinkable hydrogels formed from modified starch and O-carboxymethyl chitosan".rsc advances 5.38(2015):30303-30309. |
入库方式： OAI收割
来源：长春应用化学研究所
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