Multifunctional polyelectrolyte multilayers coated onto Gd2O3:Yb3+,Er3+@MSNs can be used as drug carriers and imaging agents
文献类型：期刊论文
| 作者 | Huang,Shanshan; Cheng,Ziyong; Chen,Yinyin; Liu,Bei; Deng,Xiaoran; Ma,Ping'an; Lin,Jun |
| 刊名 | rsc advances
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:52页码:41985-41993 |
| 关键词 | MESOPOROUS SILICA NANOPARTICLES CORE-SHELL STRUCTURE MAGNETIC-RESONANCE IN-SITU DELIVERY PROPERTIES RELEASE DOXORUBICIN LUMINESCENCE FABRICATION TUMOR |
| 通讯作者 | lin,j |
| 英文摘要 | mesoporous silica nanoparticles (msns) were firstly functionalized with upconversion luminescent gd2o3:yb3+, er3+ via the pechini sol-gel method. then, polyelectrolyte multilayers (pem) composed of poly(allyamine hydrochloride) (pah) and poly(styrene sulfonate) (pss) were coated onto the gd2o3:yb3+, er3+@msns using a layer-by-layer (lbl) technique to achieve the ph-responsive properties of the nanocarriers. pem@gd2o3:yb3+, er3+@msns loaded with doxorubicin hydrochloride (dox) showed ph-responsive release and higher cytotoxicity towards mcf-7 breast cancer cells in vitro. nanocomposites functionalized with gd2o3:yb3+, er3+ can serve as t-1-weighted magnetic resonance imaging (mri) contrast agents. nanoparticles emitting red signals under 980 nm laser excitation are suitable for use in potential bioimaging applications. the upconversion luminescent (ucl) intensity of pem-coated nanocomposites can be adjusted by controlling the number of layers of the pah/pss coating. the pem@gd2o3:yb3+, er3+@msns can be used as a potential drug delivery system for mri, ucl imaging, and ph-responsive chemotherapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-31 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/67844]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Huang,Shanshan,Cheng,Ziyong,Chen,Yinyin,et al. Multifunctional polyelectrolyte multilayers coated onto Gd2O3:Yb3+,Er3+@MSNs can be used as drug carriers and imaging agents[J]. rsc advances,2015,5(52):41985-41993. |
| APA | Huang,Shanshan.,Cheng,Ziyong.,Chen,Yinyin.,Liu,Bei.,Deng,Xiaoran.,...&Lin,Jun.(2015).Multifunctional polyelectrolyte multilayers coated onto Gd2O3:Yb3+,Er3+@MSNs can be used as drug carriers and imaging agents.rsc advances,5(52),41985-41993. |
| MLA | Huang,Shanshan,et al."Multifunctional polyelectrolyte multilayers coated onto Gd2O3:Yb3+,Er3+@MSNs can be used as drug carriers and imaging agents".rsc advances 5.52(2015):41985-41993. |
入库方式： OAI收割
来源：长春应用化学研究所
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