A pH sensitive co-delivery system of siRNA and doxorubicin for pulmonary administration to B16F10 metastatic lung cancer
文献类型：期刊论文
| 作者 | Xu,Caina; Tian,Huayu; Sun,Hai; Jiao,Zixue; Zhang,Ying; Chen,Xuesi |
| 刊名 | rsc advances
 |
| 出版日期 | 2015 |
| 卷号 | 5期号:125页码:103380-103385 |
| 关键词 | CHARGE-CONVERSION SYSTEM DRUG-DELIVERY INHALATION TREATMENT RNA INTERFERENCE NANOPARTICLES STRATEGIES THERAPY DNA CODELIVERY MICELLES |
| 通讯作者 | tian,hy |
| 英文摘要 | pulmonary co-delivery to the lungs offers a potential therapy for pulmonary diseases. in this study, doxorubicin was conjugated to polyethyleneimine by hydrazone bonds to form a ph sensitive conjugate (pei-hz-dox). a co-delivery carrier was constructed by complexing bcl2 sirna with pei-hz-dox. the complex particles could be used by pulmonary administration for metastatic lung cancer treatment. dox release from the pei-hz-dox conjugate was in a ph-dependent pattern and accelerated by decreasing ph. the cell uptake of dox and sirna from pei-hz-dox/sirna and efficient intracellular release of dox from pei-hz-dox in b16f10 cells were further confirmed. cell apoptosis and antitumor effects of the combined therapy were evaluated in vitro, the results showed that co-delivery of dox and sirna had better antitumor efficacy than mono-delivery of dox or sirna. furthermore, the biodistribution results showed that pulmonary administration could improve the deposition amounts of dox and sirna in the lungs and prolong the retention time compared with systemic administration, which demonstrated that the present delivery system is suitable for pulmonary co-delivery. overall, ph sensitive pei-hz-dox/sirna complex nanoparticles exhibit great potential for clinical combination therapy of lung cancer by pulmonary administration in local delivery strategies. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-31 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/67870]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu,Caina,Tian,Huayu,Sun,Hai,et al. A pH sensitive co-delivery system of siRNA and doxorubicin for pulmonary administration to B16F10 metastatic lung cancer[J]. rsc advances,2015,5(125):103380-103385. |
| APA | Xu,Caina,Tian,Huayu,Sun,Hai,Jiao,Zixue,Zhang,Ying,&Chen,Xuesi.(2015).A pH sensitive co-delivery system of siRNA and doxorubicin for pulmonary administration to B16F10 metastatic lung cancer.rsc advances,5(125),103380-103385. |
| MLA | Xu,Caina,et al."A pH sensitive co-delivery system of siRNA and doxorubicin for pulmonary administration to B16F10 metastatic lung cancer".rsc advances 5.125(2015):103380-103385. |
入库方式： OAI收割
来源：长春应用化学研究所
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