Effects of Chain Rigidity on the Adsorption of a Polyelectrolyte Chain on Mixed Lipid Monolayer: A Monte Carlo Study
文献类型：期刊论文
| 作者 | Duan,Xiaozheng; Ding,Mingming; Zhang,Ran; Li,Liangyi; Shi,Tongfei; An,Lijia; Huang,Qingrong; Xu,Wen-Sheng |
| 刊名 | journal of physical chemistry b
 |
| 出版日期 | 2015 |
| 卷号 | 119期号:19页码:6041-6049 |
| 关键词 | PLASMA-MEMBRANE PHOSPHATIDYLINOSITOL 4 CHARGED SURFACE PROTEIN DYNAMICS BINDING PIP2 DOMAIN SIMULATIONS PHOSPHATIDYLSERINE 5-BISPHOSPHATE |
| 通讯作者 | shi,tf |
| 英文摘要 | we apply monte carlo simulation to explore the adsorption of a positively charged polyelectrolyte on a lipid monolayer membrane, composed of electronically neutral, monovalent anionic and mulvitalent anionic phospholipids. we systematically assess the influence of various factors, including the intrinsic rigidity of the polyelectrolyte chain, the bead charge density of the polyelectrolyte, and the ionic strength of the saline solution, on the interfacial structural properties of the polyelectrolyte/monolayer complex. the enhancement of the polyelectrolyte chain intrinsic rigidity reduces the polyelectrolyte conformational entropy loss and the energy gains in electrostatic interaction, but elevates the segregated anionic lipid demixing entropy loss. this energy-entropy competition results in a nonmonotonic dependence of the polyelectrolyte/monolayer association strength on the degree of chain rigidity. the semiflexible polyelectrolyte, i.e., the one with an intermediate degree of chain rigidity, is shown to associate onto the ternary membane below a higher critical ionic concentration. in this ionic concentration regime, the semiflexible polyelectrolyte binds onto the monolayer more firmly than the pancake-like flexible one and exhibits a stretched conformation. when the chain is very rigid, the polyelectrolyte with bead charge density z(b) = +1 exhibits a larger tail and tends to dissociate from the membrane, whereas the one with z(b) = +2 can still bind onto the membrane in a bridge-like conformation. our results imply that chain intrinsic rigidity serves as an efficient molecular factor for tailoring the adsorption/desorption transition and interfacial structure of the polyelectrolyte/monolayer complex. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-31 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/67923]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Duan,Xiaozheng,Ding,Mingming,Zhang,Ran,et al. Effects of Chain Rigidity on the Adsorption of a Polyelectrolyte Chain on Mixed Lipid Monolayer: A Monte Carlo Study[J]. journal of physical chemistry b,2015,119(19):6041-6049. |
| APA | Duan,Xiaozheng.,Ding,Mingming.,Zhang,Ran.,Li,Liangyi.,Shi,Tongfei.,...&Xu,Wen-Sheng.(2015).Effects of Chain Rigidity on the Adsorption of a Polyelectrolyte Chain on Mixed Lipid Monolayer: A Monte Carlo Study.journal of physical chemistry b,119(19),6041-6049. |
| MLA | Duan,Xiaozheng,et al."Effects of Chain Rigidity on the Adsorption of a Polyelectrolyte Chain on Mixed Lipid Monolayer: A Monte Carlo Study".journal of physical chemistry b 119.19(2015):6041-6049. |
入库方式： OAI收割
来源：长春应用化学研究所
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