Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate
文献类型：期刊论文
| 作者 | Sun,Tingting; Guan,Xingang; Zheng,Min; Jing,Xiabin; Xie,Zhigang |
| 刊名 | acs medicinal chemistry letters
 |
| 出版日期 | 2015 |
| 卷号 | 6期号:4页码:430-433 |
| 关键词 | SQUAMOUS-CELL CARCINOMA CISPLATIN RESISTANCE CANCER-CELLS TUMOR-CELLS DRUG DNA CHEMORESISTANCE DELIVERY ASPIRIN AGENTS |
| 通讯作者 | xie,zg |
| 英文摘要 | a convenient synthesis of a bodipy (1,3,5,7-tetramethyl-8-(4-pyridyl)-4,4'-difluoroboradiazaindacene) labeled platinum compound (bodipy-pt) was developed by direct conjugation of cisplatin with the pyridine group of bodipy. the membrane permeability and selective uptake of bodipy-pt in the mitochondria was studied using confocal laser scanning microscopy (clsm). the fluorescent bodipy-pt conjugate showed high cellular proliferation inhibition against human cervical carcinoma (hela) and human breast cancer (mcf-7) cells, with half maximal inhibitory concentrations (ic50) of 27.37 and 12.14 mu m, respectively. this work highlights the potential of using bodipy labeled pt compounds to realize the visualization of pt distribution in living cells. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-31 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/67929]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Sun,Tingting,Guan,Xingang,Zheng,Min,et al. Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate[J]. acs medicinal chemistry letters,2015,6(4):430-433. |
| APA | Sun,Tingting,Guan,Xingang,Zheng,Min,Jing,Xiabin,&Xie,Zhigang.(2015).Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate.acs medicinal chemistry letters,6(4),430-433. |
| MLA | Sun,Tingting,et al."Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate".acs medicinal chemistry letters 6.4(2015):430-433. |
入库方式： OAI收割
来源：长春应用化学研究所
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