Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy
文献类型：期刊论文
| 作者 | Zhang,Yanbo; Ding,Jianxun; Sun,Diankui; Sun,Hai; Zhuang,Xiuli; Chang,Fei; Wang,Jincheng; Chen,Xuesi |
| 刊名 | materials science & engineering c-biomimetic and supramolecular systems
 |
| 出版日期 | 2015 |
| 卷号 | 49期号:4页码:262-268 |
| 关键词 | CELL LUNG-CANCER CONTROLLED-RELEASE BIOMEDICAL APPLICATIONS BLOCK-COPOLYMER DOXORUBICIN SYSTEMS HYDROGELS THERAPY VITRO NANOPARTICLES |
| 通讯作者 | ding,jx |
| 英文摘要 | in the past few decades, the in situ sustained drug delivery platforms present fascinating potential in sentinel chemotherapy of various solid tumors. in this work, doxorubicin (dox), a model antitumor drug, was loaded into the thermogel of poly(lactide-co-glycolide)-block-poly( ethylene glycol)-block-poly(lactide-co-glycolide). the moderate mechanical property of dox-loaded hydrogel was confirmed by rheological test. in vitro degradation revealed the good biodegradability of thermogel. the dox-loaded hydrogel exhibited the sustained release profiles up to 30 days without and even with elastase. the improved in vivo tumor inhibition and reduced side-effects were observed in the dox-incorporated hydrogel group compared with those in free dox group. the excellent in vivo results were further confirmed by the histopathological evaluation or terminal deoxynucleotidyl transferase-mediated dutp nick-end labeling assay. the thermogel with great prospect may be used as an ideal controlled drug delivery platform for the designated and long-term antitumor chemotherapy. (c) 2015 elsevier b.v. all rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000350514100029 |
| 公开日期 | 2016-05-31 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/67933]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhang,Yanbo,Ding,Jianxun,Sun,Diankui,et al. Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy[J]. materials science & engineering c-biomimetic and supramolecular systems,2015,49(4):262-268. |
| APA | Zhang,Yanbo.,Ding,Jianxun.,Sun,Diankui.,Sun,Hai.,Zhuang,Xiuli.,...&Chen,Xuesi.(2015).Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy.materials science & engineering c-biomimetic and supramolecular systems,49(4),262-268. |
| MLA | Zhang,Yanbo,et al."Thermogel-mediated sustained drug delivery for in situ malignancy chemotherapy".materials science & engineering c-biomimetic and supramolecular systems 49.4(2015):262-268. |
入库方式： OAI收割
来源：长春应用化学研究所
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