Enhancing Antibody Response against Small Molecular Hapten with Tobacco Mosaic Virus as a Polyvalent Carrier
文献类型：期刊论文
| 作者 | Zhao,Xia; Chen,Limin; Luckanagul,Jittima Amie; Zhang,Xiaolei; Lin,Yuan; Wang,Qian |
| 刊名 | chembiochem
 |
| 出版日期 | 2015 |
| 卷号 | 16期号:9页码:1279-1283 |
| 关键词 | VIRAL NANOPARTICLES SURFACE MODIFICATION IMMUNE-RESPONSES ANTIGEN PATTERNS IN-VIVO VACCINE MICE INDUCTION CELLS PARTICLES |
| 通讯作者 | lin,y |
| 英文摘要 | virus nanoparticles (vnps) have been applied as carrier proteins for effective vaccine development. in this paper, we report the usage of tobacco mosaic virus (tmv) as a carrier for the display of the small molecule estriol (e3), a weakly immunogenic hapten. a highly efficient copper (i)-catalyzed azide-alkyne cycloaddition reaction (cuaac) was performed for the conjugation of e3 onto tmv capsid at tyrosine (tyr) 139, by which the antigen density could be controlled. the immune properties of these constructs were evaluated in mice. we found that a strong and long-term antibody response was elicited by conjugating a high density of small molecular haptens on tmv through an oligo(ethylene glycol) (oeg) linker, likely due to the effective activation of b-cells. this study suggests that tmv can serve as a promising platform to induce strong humoral immune responses and that the optimized conjugation strategy was critical to produce high quality antibodies. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-31 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/67934]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhao,Xia,Chen,Limin,Luckanagul,Jittima Amie,et al. Enhancing Antibody Response against Small Molecular Hapten with Tobacco Mosaic Virus as a Polyvalent Carrier[J]. chembiochem,2015,16(9):1279-1283. |
| APA | Zhao,Xia,Chen,Limin,Luckanagul,Jittima Amie,Zhang,Xiaolei,Lin,Yuan,&Wang,Qian.(2015).Enhancing Antibody Response against Small Molecular Hapten with Tobacco Mosaic Virus as a Polyvalent Carrier.chembiochem,16(9),1279-1283. |
| MLA | Zhao,Xia,et al."Enhancing Antibody Response against Small Molecular Hapten with Tobacco Mosaic Virus as a Polyvalent Carrier".chembiochem 16.9(2015):1279-1283. |
入库方式： OAI收割
来源：长春应用化学研究所
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