Immune-microassay with optical proteinchip for protein detection
文献类型：会议论文
| 作者 | Jin G(靳刚) ; Wang ZH; Qi C; Zhao ZY; Chen S(陈涉); Meng YH; Ying PQ; Xia LH; Wan LJ
|
| 出版日期 | 2003 |
| 会议名称 | 25th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society |
| 会议日期 | SEP 17-21, 2003 |
| 会议地点 | Cancun, MEXICO |
| 通讯作者 | Jin, G (reprint author), Chinese Acad Sci, Natl Micrograv Lab, Inst Mech, Beijing 100080, Peoples R China. |
| 中文摘要 | An optical proteinchip upon antigen-antibody affinity and the chip analysis system have been used in immune analysis. The chip is processed with chip design, surface patterning, surface modification, ligand immobilization to form a microarray with many immune probes - one kind of antigen (or antibody) occupying one unit in the microarray and many such units in matrix. In micro-reactor of bio-molecule interaction, when ligand met its receptor, they would bind into bio-specific complex, which resulted in the thickness of the probe surface layer (surface concentration of antigen-antibody) increasing. The variation of protein pattern on the chip surface corresponding to the ligand immobilization and protein interactions was screened with optical imaging ellipsometry. A non-labeling micro-assay for protein detection was realized with antigen-antibody affinity and non-disturbance optical sampling, which was available for the direct test of crude samples, such as serum, etc. Some application results in immune analysis were presented also. |
| 收录类别 | CPCI-S ; EI |
| 会议录 | PROCEEDINGS OF THE 25TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-4: A NEW BEGINNING FOR HUMAN HEALTH
 |
| 会议录出版者 | IEEE |
| 会议录出版地 | NEW YORK |
| 语种 | 英语 |
| ISBN号 | 0-7803-7789-3 |
| WOS记录号 | WOS:000189395300931 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/58930]  |
| 专题 | 力学研究所_力学所知识产出(1956-2008) |
| 推荐引用方式 GB/T 7714 | Jin G,Wang ZH,Qi C,et al. Immune-microassay with optical proteinchip for protein detection[C]. 见:25th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society. Cancun, MEXICO. SEP 17-21, 2003. |
入库方式： OAI收割
来源：力学研究所
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