A metabolomic study on the responses of daphnia magna exposed to silver nitrate and coated silver nanoparticles
文献类型：期刊论文
| 作者 | Li, LZ ; Wu, HF; Ji, CL; van Gestel, CAM; Allen, HE; Peijnenburg, WJGM
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| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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| 出版日期 | 2015-09 |
| 卷号 | 119页码:66-73 |
| 关键词 | Daphnia magna Silver nanoparticle Metabolomics Silver ion Sublethal toxicity |
| ISSN号 | 0147-6513 |
| 产权排序 | [Li, LianZhen; Wu, Huifeng; Ji, Chenglong] Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Environm Proc,YICCA, Yantai 264003, Shandong, Peoples R China; [van Gestel, Cornelis A. M.] Vrije Univ Amsterdam, Fac Earth & Life Sci, Dept Ecol Sci, NL-1081 HV Amsterdam, Netherlands; [Allen, Herbert E.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA; [Peijnenburg, Willie J. G. M.] Natl Inst Publ Hlth & Environm, Ctr Safety Subst & Prod, NL-3720 BA Bilthoven, Netherlands; [Peijnenburg, Willie J. G. M.] Leiden Univ, Inst Environm Sci CML, Leiden, Netherlands |
| 通讯作者 | Wu, HF (reprint author), Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Environm Proc,YICCA, 17,Chunhui Rd, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn |
| 英文摘要 | We examined the short-term toxicity of AgNPs and AgNO3 to Daphnia magna at sublethal levels using H-1 NMR-based metabolomics. Two sizes of polyvinylpyrrolidone-coated AgNPs (10 and 40 nm) were synthesized and characterized and their Ag+ release was studied using centrifugal ultrafiltration and inductively coupled plasma mass spectrometry. Multivariate statistical analysis of the H-1 NMR spectra showed significant changes in the D. magna metabolic profiles following 48 h exposure to both AgNP particle sizes and Ag+ exposure. Most of the metabolic biomarkers for AgNP exposure, including 3-hydroxybutyrate, arginine, lysine and phosphocholine, were identical to those of the Ag+-exposed groups, suggesting that the dominant effects of both AgNPs were due to released Ag+. The observed metabolic changes implied that the released Ag+ induced disturbance in energy metabolism and oxidative stress, a proposed mechanism of AgNP toxicity. Elevated levels of lactate in all AgNP-treated but not in Ag+-treated groups provided evidence for Ag-NP enhanced anaerobic metabolism. These findings show that H-1 NMR-based metabolomics provides a sensitive measure of D. magna response to AgNPs and that further targeted assays are needed to elucidate mechanisms of action of nanoparticle-induced toxicity. (C) 2015 Elsevier Inc. All rights reserved. |
| 学科主题 | Environmental Sciences & Ecology ; Toxicology |
| 研究领域[WOS] | Environmental Sciences ; Toxicology |
| 关键词[WOS] | TOXICITY ; NMR ; EXTRACTION ; ORGANISMS ; STRESS ; ACID ; RATS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356841200008 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/13813]  |
| 专题 | 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, LZ,Wu, HF,Ji, CL,et al. A metabolomic study on the responses of daphnia magna exposed to silver nitrate and coated silver nanoparticles[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2015,119:66-73. |
| APA | Li, LZ,Wu, HF,Ji, CL,van Gestel, CAM,Allen, HE,&Peijnenburg, WJGM.(2015).A metabolomic study on the responses of daphnia magna exposed to silver nitrate and coated silver nanoparticles.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,119,66-73. |
| MLA | Li, LZ,et al."A metabolomic study on the responses of daphnia magna exposed to silver nitrate and coated silver nanoparticles".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 119(2015):66-73. |
入库方式： OAI收割
来源：烟台海岸带研究所
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