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Bio-distribution and metabolic paths of silica coated CdSeS quantum dots

文献类型：期刊论文

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作者Chen Z(陈真); Meng H(孟幻); Xing GM(邢更妹); Gao XY(高学云); Sun BY(孙宝云); Yuan H(袁慧); Zhang CC(张程程); Zhao F(赵峰); Zhao YL(赵宇亮); Chen, Z
刊名TOXICOLOGY AND APPLIED PHARMACOLOGY ; TOXICOLOGY AND APPLIED PHARMACOLOGY
出版日期2008 ; 2008
卷号230期号:3页码:364-371
关键词quantum dot bio-kinetics metabolic path nanoparticle ICP-MS quantum dot bio-kinetics metabolic path nanoparticle ICP-MS
DOI10.1016/j.taap.2008.03.022
通讯作者[Chen, Zhen ; Meng, Huan ; Xing, Gengmei ; Gao, Xueyun ; Sun, Baoyun ; Yuan, Hui ; Zhang, Chengcheng ; Zhao, Feng ; Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Zhao, Yuliang] Natl Ctr Nanosci & Technol China, Beijing 100080, Peoples R China ; [Chen, Hu] Guizhou Normal Univ, Inst S China Karst, Guiyang 550001, Peoples R China ; [Shi, Xiaoli ; Fang, Xiaohong] Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China ; [Chen, Zhen ; Meng, Huan ; Shi, Xiaoli ; Zhang, Chengcheng ; Liu, Ru ; Zhao, Yuliang] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China ; [Chen, Zhen ; Meng, Huan ; Xing, Gengmei ; Gao, Xueyun ; Sun, Baoyun ; Yuan, Hui ; Zhang, Chengcheng ; Zhao, Feng ; Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Zhao, Yuliang] Natl Ctr Nanosci & Technol China, Beijing 100080, Peoples R China ; [Chen, Hu] Guizhou Normal Univ, Inst S China Karst, Guiyang 550001, Peoples R China ; [Shi, Xiaoli ; Fang, Xiaohong] Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China ; [Chen, Zhen ; Meng, Huan ; Shi, Xiaoli ; Zhang, Chengcheng ; Liu, Ru ; Zhao, Yuliang] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
文献子类Article
英文摘要With the rapid development of quantum dot (QD) technology, water-soluble QDs have the prospect of being used as a biological probe for specific diagnoses, but their biological behaviors in vivo are little known. Our recent in vivo studies concentrated on the bio-kinetics of QDs coated by hydroxyl group modified silica networks (the QDs are 21.3 +/- 2.0 nm in diameter and have maximal emission at 570 nm). Male ICR mice were intravenously given the water-soluble QDs with a single dose of 5 nmol/mouse. Inductively coupled plasma-mass spectrometry was used to measure the Cd-111 content to indicate the concentration of QDs in plasma, organs, and excretion samples collected at predetermined time intervals. Meanwhile, the distribution and aggregation state of QDs in tissues were also investigated by pathological examination and differential centrifugation. The plasma half-life and clearance of QDs were 19.8 +/- 3.2 h and 57.3 +/- 9.2 ml/h/kg, respectively. The liver and kidney were the main target organs for QDs. The QDs metabolized in three paths depending on their distinct aggregated states in vivo. A fraction of free QDs, maintaining their original form, could be filtered by glomerular capillaries and excreted via urine as small molecules within five days. Most QDs bound to protein and aggregated into larger particles that were metabolized in the liver and excreted via feces in vivo. After five days, 8.6% of the injected dose of aggregated QDs still remained in hepatic tissue and it was difficult for this fraction to clear. (C) 2008 Published by Elsevier Inc.; With the rapid development of quantum dot (QD) technology, water-soluble QDs have the prospect of being used as a biological probe for specific diagnoses, but their biological behaviors in vivo are little known. Our recent in vivo studies concentrated on the bio-kinetics of QDs coated by hydroxyl group modified silica networks (the QDs are 21.3 +/- 2.0 nm in diameter and have maximal emission at 570 nm). Male ICR mice were intravenously given the water-soluble QDs with a single dose of 5 nmol/mouse. Inductively coupled plasma-mass spectrometry was used to measure the Cd-111 content to indicate the concentration of QDs in plasma, organs, and excretion samples collected at predetermined time intervals. Meanwhile, the distribution and aggregation state of QDs in tissues were also investigated by pathological examination and differential centrifugation. The plasma half-life and clearance of QDs were 19.8 +/- 3.2 h and 57.3 +/- 9.2 ml/h/kg, respectively. The liver and kidney were the main target organs for QDs. The QDs metabolized in three paths depending on their distinct aggregated states in vivo. A fraction of free QDs, maintaining their original form, could be filtered by glomerular capillaries and excreted via urine as small molecules within five days. Most QDs bound to protein and aggregated into larger particles that were metabolized in the liver and excreted via feces in vivo. After five days, 8.6% of the injected dose of aggregated QDs still remained in hepatic tissue and it was difficult for this fraction to clear. (C) 2008 Published by Elsevier Inc.
学科主题Pharmacology & Pharmacy; Toxicology ; Pharmacology & Pharmacy; Toxicology
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
URL标识查看原文
WOS研究方向Pharmacology & Pharmacy ; Toxicology
原文出处SCI
语种英语 ; 英语
WOS记录号WOS:000258412200014 ; WOS:000258412200014
源URL[http://ir.ihep.ac.cn/handle/311005/237173]  
专题高能物理研究所_多学科研究中心
高能物理研究所_加速器中心
高能物理研究所_粒子天体物理中心
高能物理研究所_东莞分部
作者单位中国科学院高能物理研究所
推荐引用方式
GB/T 7714		 Chen Z,Meng H,Xing GM,et al. Bio-distribution and metabolic paths of silica coated CdSeS quantum dots, Bio-distribution and metabolic paths of silica coated CdSeS quantum dots[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, TOXICOLOGY AND APPLIED PHARMACOLOGY,2008, 2008,230, 230(3):364-371, 364-371.
APA 陈真.,孟幻.,邢更妹.,高学云.,孙宝云.,...&Fang, XH.(2008).Bio-distribution and metabolic paths of silica coated CdSeS quantum dots.TOXICOLOGY AND APPLIED PHARMACOLOGY,230(3),364-371.
MLA 陈真,et al."Bio-distribution and metabolic paths of silica coated CdSeS quantum dots".TOXICOLOGY AND APPLIED PHARMACOLOGY 230.3(2008):364-371.

入库方式： OAI收割

来源：高能物理研究所

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