Brain glucose metabolic changes in patients with chronic pain due to brachial plexus avulsion: A positron emission tomography study
文献类型：期刊论文
| 作者 | Chen, FY; Tao, W; Cheng, X; Zhou, K ; Shan, BC; Yuan, XL; Hu, YS; Mang, XH; Li, YJ; Dan BC(单保慈)
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| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
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| 出版日期 | 2008 |
| 卷号 | 35期号:4页码:387-392 |
| 关键词 | neuropathic pain positron emission tomography brachial plexus avulsion prefrontal cortex thalamus orbitofrontal cortex |
| 其他题名 | 臂丛神经撕脱伤后慢性疼痛患者脑区葡萄糖代谢的研究 |
| 通讯作者 | [Chen Fu-Yong ; Tao Wei ; Hu Yong-Sheng ; Mang Xiao-Hua ; Li Yong-Jie] Capital Med Univ, Xuanwu Hosp, Beijing Inst Funct Neurosurg, Beijing 100053, Peoples R China ; [Cheng Xin] Peking Union Med Coll, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China ; [Zhou Ke] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China ; [Shan Bao-Ci ; Yuan Xiu-Li] Chinese Acad Sci, Inst High Energy Phys, Nucl Anal Lab, Beijing 100853, Peoples R China |
| 英文摘要 | Chronic pain due to brachial plexus avulsion (BPA) is a kind of refractory neuropathic pain, yet there is a lack of knowledge regarding underlying brain activity. To further identify brain regions involved in chronic pain due to BPA, fluorine-18 fluorodeoxyglucose (F-18-FDG) positron emission tomography (PET) was used to observe brain glucose metabolic changes in those patients. Five patients with chronic pain due to left-BPA, whose pain reduced more than 75% after dorsal root entry zoneotomy (DREZotomy) were selected. The visual analog scale (VAS), Hamilton depression scale, Hamilton anxiety scale and F-18-FDG PET of brain were recorded before and 14 days after DREZotomy respectively. Statistical parametric mapping 2 (SPM2) was applied for data analysis. Comparing with PET during pain before DREZotomy, PET after DREZotomy showed significant glucose metabolism decreases in bilateral caudate, orbitofrontal cortex (OFC) (BA 11), contralateral subgenual cingulate (BA25) and ipsilateral dorsolateral prefrontal cortex (DLPFC) (BA46/47), and significant glucose metabolism increases in contralateral thalamus, pulvinar and ipsilateral parietal lobe (BA7). The results suggested that the brain areas involved in emotion, attention and internal modulation of pain play an important role in the modulation of chronic pain due to BPA. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000255316400005 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/237273]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Chen, FY,Tao, W,Cheng, X,et al. Brain glucose metabolic changes in patients with chronic pain due to brachial plexus avulsion: A positron emission tomography study[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2008,35(4):387-392. |
| APA | Chen, FY.,Tao, W.,Cheng, X.,Zhou, K.,Shan, BC.,...&袁秀丽.(2008).Brain glucose metabolic changes in patients with chronic pain due to brachial plexus avulsion: A positron emission tomography study.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,35(4),387-392. |
| MLA | Chen, FY,et al."Brain glucose metabolic changes in patients with chronic pain due to brachial plexus avulsion: A positron emission tomography study".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 35.4(2008):387-392. |
入库方式： OAI收割
来源：高能物理研究所
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