Study of rare earth encapsulated carbon nanomolecules for biomedical uses
文献类型：期刊论文
| 作者 | Qu L(屈力); Cao WB(曹文彬); Xing GM(邢更妹) ; Zhang J(张俊); Yuan H(袁慧); Tang J(唐军); Cheng Y(程悦); Zhang B(张波); Zhao YL(赵宇亮); Qu, L
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| 刊名 | JOURNAL OF ALLOYS AND COMPOUNDS
 |
| 出版日期 | 2006 |
| 卷号 | 408页码:400-404 |
| 关键词 | Gd-metallofullerenol Gd@C-82(OH)(22) stability MRI contrast agent in vivo |
| 通讯作者 | Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100039, Peoples R China ; Chinese Acad Sci, Inst Phys & Math, State Key Lab Nucl Magnet Resonance & Atom & Mol, Wuhan 430071, Peoples R China |
| 英文摘要 | Gd@C-82(OH)(40) has been proposed to be as a new generation of the magnetic resonance imaging (MRI) contrast agent, but water-soluble fullerenols Gd@C-82(OH)(n) with n > 36 can easily lead to open-caged structures of a high instability. This restricts the practical bio-uses of Gd-metallofullerenols with a large number of hydroxyl groups. To explore how the imaging efficiency varies with decreasing hydroxyl number in Gd@C-82(OH)(22) of a good stability in vivo, Gd@C-82(OH)(22) was prepared, characterized and its imaging efficiency in mice was studied. This work aims at searching a chemical form of water-soluble Gd-metallofullerenols that satisfy both requirements of the good stability and high imaging efficiency in vivo. The results indicate that the proton relaxivity of Gd@C-82(OH)(22) is lower than that of Gd@C-82(OH)(40), but still higher than the commercial Gd-DTPA MRI contrast agent. (c) 2005 Elsevier B.V. All rights reserved. |
| 学科主题 | Chemistry; Materials Science; Metallurgy & Metallurgical Engineering |
| 类目[WOS] | Chemistry, Physical ; Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering |
| 研究领域[WOS] | Chemistry ; Materials Science ; Metallurgy & Metallurgical Engineering |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000235445300097 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/237329]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Qu L,Cao WB,Xing GM,et al. Study of rare earth encapsulated carbon nanomolecules for biomedical uses[J]. JOURNAL OF ALLOYS AND COMPOUNDS,2006,408:400-404. |
| APA | 屈力.,曹文彬.,邢更妹.,张俊.,袁慧.,...&Lei, H.(2006).Study of rare earth encapsulated carbon nanomolecules for biomedical uses.JOURNAL OF ALLOYS AND COMPOUNDS,408,400-404. |
| MLA | 屈力,et al."Study of rare earth encapsulated carbon nanomolecules for biomedical uses".JOURNAL OF ALLOYS AND COMPOUNDS 408(2006):400-404. |
入库方式： OAI收割
来源：高能物理研究所
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