Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease
文献类型：期刊论文
| 作者 | Luo, YF; Zhang, J ; Liu NQ(刘年庆); Liu, NQ; Luo, Y; Zhao, BL
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| 刊名 | SCIENCE CHINA-LIFE SCIENCES
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| 出版日期 | 2011 |
| 卷号 | 54期号:6页码:527-534 |
| 关键词 | Alzheimer's disease beta-amyloid(1-42) copper C. elegans oxidative stress |
| 通讯作者 | [Luo YunFeng ; Zhao BaoLu] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China ; [Luo YunFeng] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China ; [Zhang Jie] Rutgers State Univ, Dept Cell Biol, Piscataway, NJ 08854 USA ; [Liu NianQing] Chinese Acad Sci, Inst High Energy Phys, Synchrotron Radiat Lab, Beijing 100049, Peoples R China ; [Luo Yuan] Univ Maryland, Dept Pharmaceut Sci, Baltimore, MD 21201 USA |
| 英文摘要 | beta-amyloid (A beta) and copper play important roles in the pathogenesis of Alzheimer's disease (AD). However, the behavioral correlativity and molecular mechanisms of A beta and copper toxicity have been investigated less often. In the present study, we investigated the interaction and toxicity of A beta 1-42 and copper in the A beta 1-42 transgenic Caenorhabditis elegans worm model CL2006. Our data show that the paralysis behavior of CL2006 worms significantly deteriorated after exposure to 10(-3) mol L(-1) copper ions. However, the paralysis behavior was dramatically attenuated with exposure to 10(-4) mol L(-1) copper ions. The exogenous copper treatment also partially changed the homeostatic balance of zinc, manganese, and iron. Our data suggest that the accumulation of reactive oxygen species (ROS) was responsible for the paralysis induced by A beta and copper in CL2006. The ROS generation induced by A beta and copper appear to be through sod-1, prdx-2, skn-1, hsp-60 and hsp-16.2 genes. |
| 学科主题 | Life Sciences & Biomedicine - Other Topics |
| 类目[WOS] | Biology |
| 研究领域[WOS] | Life Sciences & Biomedicine - Other Topics |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000292050500005 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/237832]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Luo, YF,Zhang, J,Liu NQ,et al. Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease[J]. SCIENCE CHINA-LIFE SCIENCES,2011,54(6):527-534. |
| APA | Luo, YF,Zhang, J,刘年庆,Liu, NQ,Luo, Y,&Zhao, BL.(2011).Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease.SCIENCE CHINA-LIFE SCIENCES,54(6),527-534. |
| MLA | Luo, YF,et al."Copper ions influence the toxicity of beta-amyloid(1-42) in a concentration-dependent manner in a Caenorhabditis elegans model of Alzheimer's disease".SCIENCE CHINA-LIFE SCIENCES 54.6(2011):527-534. |
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来源：高能物理研究所
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