Element analysis in femur of diabetic osteoporosis model by SRXRF microprobe
文献类型：期刊论文
| 作者 | Fei, YR; Zhang, M; Li, M ; Huang, YY; He, W; Ding, WJ; Yang, JH; Huang YY(黄宇营); He W(何伟)
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| 刊名 | MICRON
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| 出版日期 | 2007 |
| 卷号 | 38期号:6页码:637-642 |
| 关键词 | osteoporosis diabetes element analysis synchrotron radiation X-ray fluorescence microbe |
| 通讯作者 | Grad Univ, Chinese Acad Sci, Dept Biol, Beijing 100049, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Facil, Beijing 100049, Peoples R China |
| 英文摘要 | Diabetes mellitus affects bone metabolism and leads to osteopenia and osteoporosis, but its pathogenic mechanism remains unknown. To address this problem, mineral element of bone was analyzed in experimental diabetic osteoporosis model. Male Wistar rats were randomly divided into streptozotocin (STZ)-induced diabetic group (n = 5) and control group (n = 5). The experiment lasted 68 days and at the end of the experiment, femoral bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry and element content in femur of animals was determined by synchrotron radiation X-ray fluorescence (SRXRF) microprobe analysis technique. Results showed that femoral BMD in diabetic group was significantly lower than that in control (P < 0.01). Relative mineral content of calcium (Ca), phosphor-us (P) and zinc (Zn) in diabetic femurs decreased significantly compared to controls. And strontium (Sr) in diabetics reduced 11% (P = 0.09). Relative content of sulfur(S) in average was statistically higher (P < 0.01) in diabetics than that in controls. But no obvious difference was observed in relative content of chromium (Cr), iron (Fe), copper (Cu), and lead (Ph) between the two groups. Statistical analysis revealed that Ca correlated positively with P (R = 0.85 and P < 0.001), with Sr (R = 0.38 and P < 0.05) and with Zn (R = 0.37 and P < 0.05). Whereas, Zn correlated negatively with S (R = -0.40 and P < 0.05). Our results reveal that loss of minerals accounts for the BMD reduction in diabetics. (C) 2006 Elsevier Ltd. All rights reserved. |
| 学科主题 | Microscopy |
| 类目[WOS] | Microscopy |
| 研究领域[WOS] | Microscopy |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000246629400013 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/238164]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_粒子天体物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Fei, YR,Zhang, M,Li, M,et al. Element analysis in femur of diabetic osteoporosis model by SRXRF microprobe[J]. MICRON,2007,38(6):637-642. |
| APA | Fei, YR.,Zhang, M.,Li, M.,Huang, YY.,He, W.,...&何伟.(2007).Element analysis in femur of diabetic osteoporosis model by SRXRF microprobe.MICRON,38(6),637-642. |
| MLA | Fei, YR,et al."Element analysis in femur of diabetic osteoporosis model by SRXRF microprobe".MICRON 38.6(2007):637-642. |
入库方式： OAI收割
来源：高能物理研究所
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