Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials
文献类型：期刊论文
| 作者 | Liang, XJ; Chen CY(陈春英); Zhao YL(赵宇亮) ; Chen, CY; Zhao, YL; Jia, L; Wang, PC
|
| 刊名 | CURRENT DRUG METABOLISM
 |
| 出版日期 | 2008 |
| 卷号 | 9期号:8页码:697-709 |
| 关键词 | Metabolism engineered nanomaterials nanomedicine fullerenol carbon nanotube titanium dioxide (TiO2) silica dioxide (SiO2) magnetic nanoparticles |
| 通讯作者 | [Liang, Xing-Jie ; Chen, Chunying ; Zhao, Yuliang] Natl Ctr Nanosci & Technol China, Div Nanomed & Nanobiol, Lab Nanobiomed & Nanosafety, Beijing, Peoples R China ; [Chen, Chunying ; Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Jia, Lee] NCI, Toxicol & Pharmacol Branch, Div Canc Treatment & Diag, NIH, Rockville, MD 20852 USA ; [Wang, Paul C.] Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA |
| 英文摘要 | Engineered nanomaterials are at the leading edge of the rapidly developing nanosciences and are founding an important class of new materials with specific physicochemical properties different from bulk materials with the same compositions. The potential for nanomaterials is rapidly expanding with novel applications constantly being explored in different areas. The unique size-dependent properties of nanomaterials make them very attractive for pharmaceutical applications. Investigations of physical, chemical and biological properties of engineered nanomaterials have yielded valuable information. Cytotoxic effects of certain engineered nanomaterials towards malignant cells form the basis for one aspect of nanomedicine. It is inferred that size, three dimensional shape, hydrophobicity and electronic configurations make them an appealing subject in medicinal chemistry. Their unique structure coupled with immense scope for derivatization forms a base for exciting developments in therapeutics. This review article addresses the fate of absorption, distribution, metabolism and excretion (ADME) of engineered nanoparticles in vitro and in vivo. It updates the distinctive methodology used for studying the biopharmaceutics of nanoparticles. This review addresses the future potential and safety concerns and genotoxicity of nanoparticle formulations in general. It particularly emphasizes the effects of nanoparticles on metabolic enzymes as well as the parenteral or inhalation administration routes of nanoparticle formulations. This paper illustrates the potential of nanomedicine by discussing biopharmaceutics of fullerene derivatives and their suitability for diagnostic and therapeutic purposes. Future direction is discussed as well. |
| 学科主题 | Biochemistry & Molecular Biology; Pharmacology & Pharmacy |
| 类目[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000260015100003 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/238299]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Liang, XJ,Chen CY,Zhao YL,et al. Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials[J]. CURRENT DRUG METABOLISM,2008,9(8):697-709. |
| APA | Liang, XJ.,陈春英.,赵宇亮.,Chen, CY.,Zhao, YL.,...&Wang, PC.(2008).Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials.CURRENT DRUG METABOLISM,9(8),697-709. |
| MLA | Liang, XJ,et al."Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials".CURRENT DRUG METABOLISM 9.8(2008):697-709. |
入库方式： OAI收割
来源：高能物理研究所
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