Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy
文献类型：期刊论文
| 作者 | Wang, LM ; Liu, Y; Li W(李炜); Li YF(李玉锋); Zhao YL(赵宇亮); Chen CY(陈春英); Li, W; Jiang, XM; Ji, YL; Wu, XC
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| 刊名 | NANO LETTERS
 |
| 出版日期 | 2011 |
| 卷号 | 11期号:2页码:772-780 |
| 关键词 | Gold nanorods serum proteins uptake and removal intracellular localization mitochondrion-targeted nanomaterials tumor therapy |
| 通讯作者 | [Ji, Yinglu ; Wu, Xiaochun] Natl Ctr Nanosci & Technol China, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China ; [Wang, Liming ; Liu, Ying ; Jiang, Xiumei ; Xu, Ligeng ; Qiu, Yang ; Chen, Chunying] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China ; [Li, Wei ; Li, Yufeng ; Zhao, Yuliang ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Li, Wei ; Li, Yufeng ; Zhao, Yuliang ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Zhao, Kai ; Wei, Taotao] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China |
| 英文摘要 | We have observed that Au nanorods (NRs) have distinct effects on cell viability via killing cancer cells while posing negligible impact on normal cells and mesenchymal stem cells. Obvious differences in cellular uptake, intracellular trafficking, and susceptibility of lysosome to Au NRs by different types of cells resulted in selective accumulation of Au NRs in the mitochondria of cancer cells. Their long-term retention decreased mitochondrial membrane potential and increased reactive oxygen species level that enhances the likelihood of cell death. These findings thus provide guidance for the design of organelle-targeted nanomaterials in tumor therapy. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000287049100078 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/238461]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 高能物理研究所_加速器中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wang, LM,Liu, Y,Li W,et al. Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy[J]. NANO LETTERS,2011,11(2):772-780. |
| APA | Wang, LM.,Liu, Y.,李炜.,李玉锋.,赵宇亮.,...&Chen, CY.(2011).Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy.NANO LETTERS,11(2),772-780. |
| MLA | Wang, LM,et al."Selective Targeting of Gold Nanorods at the Mitochondria of Cancer Cells: Implications for Cancer Therapy".NANO LETTERS 11.2(2011):772-780. |
入库方式： OAI收割
来源：高能物理研究所
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