Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated rats
文献类型：期刊论文
| 作者 | Hui, JJ; Zhang, ZJ; Liu, SS; Xi, GJ; Zhang, XR ; Teng, GJ; Chan, KC; Wu, EX; Nie, BB; Shan, BC
|
| 刊名 | EUROPEAN NEUROPSYCHOPHARMACOLOGY
 |
| 出版日期 | 2010 |
| 卷号 | 20期号:12页码:875-883 |
| 关键词 | Hippocampus Maternal separation Escitalopram Magnetic resonance imaging Proton magnetic resonance spectroscopy Rat |
| 通讯作者 | [Hui, Jiaojie ; Zhang, Zhijun ; Liu, Shanshan ; Xi, Guangjun ; Zhang, Xiangrong] Southeast Univ, Dept Neurol, Affiliated ZhongDa Hosp, Nanjing, Jiangsu, Peoples R China ; [Hui, Jiaojie ; Zhang, Zhijun ; Liu, Shanshan ; Xi, Guangjun ; Zhang, Xiangrong ; Teng, GaoJun] Southeast Univ, Sch Clin Med, Nanjing, Jiangsu, Peoples R China ; [Teng, GaoJun] Southeast Univ, Inst Mol Imaging, Nanjing, Jiangsu, Peoples R China ; [Chan, Kevin C. ; Wu, Ed X.] Univ Hong Kong, Lab Biomed Imaging & Signal Proc, Pokfulam, Hong Kong, Peoples R China ; [Chan, Kevin C. ; Wu, Ed X.] Univ Hong Kong, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China ; [Nie, Binbin] Zhengzhou Univ, Phys Sci & Technol Coll, Zhengzhou, Henan, Peoples R China ; [Nie, Binbin ; Shan, Baoci] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing, Peoples R China ; [Li, Lingjiang] Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China ; [Reynolds, Gavin P.] Queens Univ Belfast, Dept Psychiat, Belfast BT9 7BL, Antrim, North Ireland |
| 英文摘要 | Early life stress is a potential precursor of eventual neuropsychiatric diseases and may result in altered neurodevelopment and function of the hippocampus, which thus provides a site at which potential interventions to modify the effects of early life stress may act. In this study, Sprague Dawley rat pups comprising male and female animals underwent maternal separation (MS) for 180 min from postnatal days (PND) 2 to 14, or were left with their dams. They subsequently received daily administration of saline (0.9%), escitalopram (10 mg/kg), or no treatment during adolescence (PND 43-60). All adult animals underwent brain magnetic resonance imaging (MRI) and bilateral hippocampal proton magnetic resonance spectroscopy ((1)H-MRS). Neither MS nor escitalopram treatment had a significant effect on hippocampal volume. Adult rats that experienced MS displayed significantly increased choline-containing compounds (Cho) and decreased N-acetylaspartate (NAA), glutamate (Glu) and Myo-inositol (MI) relative to the stable neurometabolite creatine (Cr) in hippocampus. Administration of escitalopram during adolescence could modify the alterations of NAA/Cr, Glu/Cr and MI/Cr. The effects of MS on hippocampal neurochemistry were most significant in the right hippocampus. These results indicate that MS in rats has long-term consequences on hippocampal neurochemistry reflective of neural density/functional integrity, especially on the right hippocampus, and adolescent administration with escitalopram can at least partially ameliorate these neurochemical alterations. Furthermore, these metabolite changes seem to be more sensitive indicators of the results from early life stress than volume changes. (C) 2010 Elsevier B.V. and ECNP. All rights reserved |
| 学科主题 | Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry |
| 类目[WOS] | Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
| 研究领域[WOS] | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000284569600006 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/238658]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_核技术应用研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Hui, JJ,Zhang, ZJ,Liu, SS,et al. Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated rats[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY,2010,20(12):875-883. |
| APA | Hui, JJ.,Zhang, ZJ.,Liu, SS.,Xi, GJ.,Zhang, XR.,...&单保慈.(2010).Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated rats.EUROPEAN NEUROPSYCHOPHARMACOLOGY,20(12),875-883. |
| MLA | Hui, JJ,et al."Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated rats".EUROPEAN NEUROPSYCHOPHARMACOLOGY 20.12(2010):875-883. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。