White-matter Volume Reduction and the Protective Effect of Immunosuppressive Therapy in Systemic Lupus Erythematosus Patients with Normal Appearance by Conventional Magnetic Resonance Imaging
文献类型：期刊论文
| 作者 | Xu, J ; Cheng, YQ; Chai P(柴培); Li L(李琳); Dan BC(单保慈); Chai, P; Lu, ZP; Li, HJ; Luo, CR; Li, XZ
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| 刊名 | JOURNAL OF RHEUMATOLOGY
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| 出版日期 | 2010 |
| 卷号 | 37期号:5页码:974-986 |
| 关键词 | WHITE MATTER SYSTEMIC LUPUS ERYTHEMATOSUS IMMUNOSUPPRESSIVE THERAPY MAGNETIC RESONANCE IMAGING |
| 通讯作者 | [Chen, Bing ; Wen, Jianfan] Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China ; Chinese Acad Sci, Grad Sch, Beijing, Peoples R China ; [Zhou, Qixin ; Cao, Jun] Chinese Acad Sci, Key Lab Anim Models & Human Dis Mechanisms, Kunming 650223, Yunnan, Peoples R China ; [Xu, Jian ; Li, Xizhi] Kunming Med Coll, Affiliated Hosp 1, Dept Rheumatol & Immunol, Kunming, Peoples R China ; [Xu, Xiufeng] Kunming Med Coll, Affiliated Hosp 1, Dept Psychiat, Kunming, Peoples R China ; [Chai, Pei ; Li, Lin ; Shan, Baoci] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Anal, Beijing, Peoples R China ; [Luo, Chunrong] First Hosp Kunming City, Magnet Resonance Imaging Ctr, Kunming, Yunnan, Peoples R China |
| 英文摘要 | Objective. The central nervous system (CNS) is often affected by systemic lupus erythematosus (SLE), but assessment of CNS outcomes using noninvasive cerebral structural measures remains in its infancy. Magnetic resonance imaging (MRI) with expert visual interpretation is critical to diagnosis, but does not permit quantitative measurements. Our pilot study investigated whether quantitative brain volumetric analyses could be used to detect white-matter (WM) abnormalities and responses to treatment in SLE (ClinicalTrials.gov: NCT00703742). Methods. Forty-two pairs of SLE patients and healthy controls underwent high-resolution 3-dimensional structural MRI scans. Combining voxel-based morphometry and region of interest analyses, subtle WM volume abnormalities in whole brains from SLE patients were identified, and regional WM volume was calculated. Associations between WM volume and symptom severity, as well as the effects of immunosuppressive therapy, were then investigated. Results. The WM volume of the SLE group was significantly decreased in the bilateral posterior and anterior crus of the internal capsule (PIC and AIC, respectively), the subgyral right frontal lobe, and left temporal lobe (p<0.001). Regional WM volume (left PIC and right AIC) was correlated with SLEDAI scores. The WM volume of patients treated with immunosuppressive therapy was greater than that of patients who were never treated with immunosuppressive therapy. Conclusion. Quantitative brain volumetric analyses detect brain injuries in WM for SLE that are not obvious by conventional MRI, and may be adequately sensitive and quantitative to measure the effect of therapeutic interventions M preventing brain injury and outcomes in SLE. (First Release March 15 2010; J Rheumatol 2010;37:974-86; doi:10.3899/jrheum.090967) |
| 学科主题 | Rheumatology |
| 类目[WOS] | Rheumatology |
| 研究领域[WOS] | Rheumatology |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000277696700017 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/238824]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 高能物理研究所_加速器中心 高能物理研究所_粒子天体物理中心 高能物理研究所_核技术应用研究中心 中国科学院高能物理研究所_中国散裂中子源 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Xu, J,Cheng, YQ,Chai P,et al. White-matter Volume Reduction and the Protective Effect of Immunosuppressive Therapy in Systemic Lupus Erythematosus Patients with Normal Appearance by Conventional Magnetic Resonance Imaging[J]. JOURNAL OF RHEUMATOLOGY,2010,37(5):974-986. |
| APA | Xu, J.,Cheng, YQ.,柴培.,李琳.,单保慈.,...&Wen, JF.(2010).White-matter Volume Reduction and the Protective Effect of Immunosuppressive Therapy in Systemic Lupus Erythematosus Patients with Normal Appearance by Conventional Magnetic Resonance Imaging.JOURNAL OF RHEUMATOLOGY,37(5),974-986. |
| MLA | Xu, J,et al."White-matter Volume Reduction and the Protective Effect of Immunosuppressive Therapy in Systemic Lupus Erythematosus Patients with Normal Appearance by Conventional Magnetic Resonance Imaging".JOURNAL OF RHEUMATOLOGY 37.5(2010):974-986. |
入库方式： OAI收割
来源：高能物理研究所
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