The effects of MESO-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus
文献类型：期刊论文
| 作者 | Zhang J(张杰); Wang XF(王雪飞); Liu NQ(刘年庆); Zhang, J ; Wang, XF; Lu, ZB; Liu, NQ; Zhao, BL
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| 刊名 | FREE RADICAL BIOLOGY AND MEDICINE
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| 出版日期 | 2004 |
| 卷号 | 37期号:7页码:1037-1050 |
| 关键词 | antioxidant apoptosis chelating DMSA hippocampus lead neurotoxicity oxidative stress OPC free radicals |
| 通讯作者 | Acad Sinica, Inst Biophys, Ctr Brain & Cognit Sci, Lab Visual Informat Proc, Beijing 100101, Peoples R China ; Acad Sinica, Inst High Energy Phys, Beijing 100039, Peoples R China |
| 英文摘要 | Oxidative stress is considered to be a mechanism involved in lead neurotoxicity. Apoptosis is also thought to relate to lead neurotoxicity. The present study, focused on the hippocampus, was designed to investigate the two possible mechanisms involved in lead neurotoxicity and the potential protective effects of 2,3-dimercaptosuccinic acid (DMSA) and oligomeric procyanidins (OPC). It was proved that reactive oxygen species and oxidative damage were implicated in the induction of apoptosis induced by lead in the hippocampus. Administration of DMSA attenuated the oxidative stress and apoptosis in addition to having strong chelating and lead-removing capacity. OPC alone had antioxidant protective effects in the hippocampus but no removing capacity for lead in vivo despite showing higher affinity and stronger chelating ability for Pb2+ than DMSA in vitro. It is suggested that OPC chelates Pb2+ but does not discharge it from the body and even accumulates Pb2+ in some organs. At the same time, a reasonable deduction can also be made that the complex of OPC-Pb2+ prevents or at least weakens the neurotoxicity of Pb2+. Whether this complex displays toxicity over a long time span should be studied further. (C) 2004 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Endocrinology & Metabolism |
| 类目[WOS] | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000224011900015 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/238936]  |
| 专题 | 高能物理研究所_实验物理中心 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhang J,Wang XF,Liu NQ,et al. The effects of MESO-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus[J]. FREE RADICAL BIOLOGY AND MEDICINE,2004,37(7):1037-1050. |
| APA | 张杰.,王雪飞.,刘年庆.,Zhang, J.,Wang, XF.,...&Zhao, BL.(2004).The effects of MESO-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus.FREE RADICAL BIOLOGY AND MEDICINE,37(7),1037-1050. |
| MLA | 张杰,et al."The effects of MESO-2,3-dimercaptosuccinic acid and oligomeric procyanidins on acute lead neurotoxicity in rat hippocampus".FREE RADICAL BIOLOGY AND MEDICINE 37.7(2004):1037-1050. |
入库方式： OAI收割
来源：高能物理研究所
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