Characterization of gold nanorods in vivo by integrated analytical techniques: their uptake, retention, and chemical forms
文献类型：期刊论文
| 作者 | Wang, LM ; Li YF(李玉锋); Li B(李柏); Chen CY(陈春英); Li, YF; Zhou, LJ; Liu, Y; Meng, L; Zhang, K; Wu, XC
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| 刊名 | ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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| 出版日期 | 2010 |
| 卷号 | 396期号:3页码:1105-1114 |
| 关键词 | Gold nanorods Biodistribution Characterization in vivo Transmission electron microscopy Inductively coupled plasma mass spectrometry X-ray absorption spectroscopy |
| 通讯作者 | [Li, Yu-Feng ; Li, Bai ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Wang, Liming ; Zhou, Liangjun ; Liu, Ying ; Meng, Li ; Zhang, Lili ; Chen, Chunying] Natl Ctr Nanosci & Technol China, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China ; [Zhang, Ke ; Wu, Xiaochun] Natl Ctr Nanosci & Technol China, Lab Nanoscale Measurement & Standardizat, Beijing 100190, Peoples R China |
| 英文摘要 | Integrated analytical techniques were used to study the tissue distribution and structural information of gold nanorods (Au NRs) in Sprague-Dawley rats through tail intravenous injection. Before in vivo experiments were conducted, careful characterization of Au NRs was performed. The zeta potential proved that adsorption of bovine serum albumin on Au NRs turned the surface charges from positive to negative as in an in vitro simulation. The biodistribution of Au NRs was investigated quantitatively by inductively coupled plasma mass spectrometry at different time points after injection. As target tissues, both liver and spleen were chosen to further demonstrate the intracellular localization of Au NRs by the combination of transmission electron microscopy and energy-dispersive X-ray spectroscopy. Moreover, synchrotron-radiation-based X-ray absorption spectroscopy was employed and it was observed that long-term retention of Au NRs in liver and spleen did not induce obvious changes in the oxidation states of gold. Therefore, the present systematic method can provide important information about the fates of Au NRs in vivo and can also be extended to study the biological effects of other metallic nanomaterials in the future. |
| 学科主题 | Biochemistry & Molecular Biology; Chemistry |
| 类目[WOS] | Biochemical Research Methods ; Chemistry, Analytical |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000273845200016 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/239051]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 高能物理研究所_加速器中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wang, LM,Li YF,Li B,et al. Characterization of gold nanorods in vivo by integrated analytical techniques: their uptake, retention, and chemical forms[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2010,396(3):1105-1114. |
| APA | Wang, LM.,李玉锋.,李柏.,陈春英.,Li, YF.,...&Chen, CY.(2010).Characterization of gold nanorods in vivo by integrated analytical techniques: their uptake, retention, and chemical forms.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,396(3),1105-1114. |
| MLA | Wang, LM,et al."Characterization of gold nanorods in vivo by integrated analytical techniques: their uptake, retention, and chemical forms".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 396.3(2010):1105-1114. |
入库方式： OAI收割
来源：高能物理研究所
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