Inhibition of tumor growth by endohedral metallofullerenol nanoparticles optimized as reactive oxygen species scavenger
文献类型：期刊论文
| 作者 | Yin, JJ; Lao, F; Meng J(孟洁); Zhao YL(赵宇亮) ; Xing GM(邢更妹); Gao XY(高学云); Sun BY(孙宝云); Chen CY(陈春英); Meng, J; Fu, PP
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| 刊名 | MOLECULAR PHARMACOLOGY
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| 出版日期 | 2008 |
| 卷号 | 74期号:4页码:1132-1140 |
| 通讯作者 | [Liang, Xing-Jie] Natl Ctr Nanosci & Technol China, Lab Nanobiomed & Nanosafety, Div Nanomed & Nanobiol, Beijing 100190, Peoples R China ; [Meng, Jie ; Zhao, Yuliang ; Xing, Gengmei ; Gao, Xueyun ; Sun, Baoyun ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing, Peoples R China ; [Yin, Jun-Jie] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD USA ; [Fu, Peter P.] US FDA, Natl Ctr Toxicol Res, Div Biochem Toxicol, Jefferson, AR 72079 USA ; [Wang, Paul C.] Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20059 USA |
| 英文摘要 | Intraperitoneal injection of [Gd@C(82)(OH)(22)](n) nanoparticles decreased activities of enzymes associated with the metabolism of reactive oxygen species (ROS) in the tumor-bearing mice. Several physiologically relevant ROS were directly scavenged by nanoparticles, and lipid peroxidation was inhibited in this study. [Gd@C(82)(OH)(22)](n) nanoparticles significantly reduced the electron spin resonance (ESR) signal of the stable 2,2-diphenyl-1-picryhydrazyl radical measured by ESR spectroscopy. Likewise, studies using ESR with spin-trapping demonstrated efficient scavenging of superoxide radical anion, hydroxyl radical, and singlet oxygen ((1)O(2)) by [Gd@C(82)(OH)(22)](n) nanoparticles. In vitro studies using liposomes prepared from bovine liver phosphatidylcholine revealed that nanoparticles also had a strong inhibitory effect on lipid peroxidation. Consistent with their ability to scavenge ROS and inhibit lipid peroxidation, we determined that [Gd@C(82)(OH)(22)](n) nanoparticles also protected cells subjected in vitro to oxidative stress. Studies using human lung adenocarcinoma cells or rat brain capillary endothelial cells demonstrated that [Gd@C(82)(OH)(22)](n) nanoparticles reduced H(2)O(2)-induced ROS formation and mitochondrial damage. [Gd@C(82)(OH)(22)](n) nanoparticles efficiently inhibited the growth of malignant tumors in vivo. In summary, the results obtained in this study reveal antitumor activities of [Gd@C(82)(OH)(22)](n) nanoparticles in vitro and in vivo. Because ROS are known to be implicated in the etiology of a wide range of human diseases, including cancer, the present findings demonstrate that the potent inhibition of [Gd@C(82)(OH)(22)](n) nanoparticles on tumor growth likely relates with typical capacity of scavenging reactive oxygen species. |
| 学科主题 | Pharmacology & Pharmacy |
| 类目[WOS] | Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259317500021 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/239096]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Yin, JJ,Lao, F,Meng J,et al. Inhibition of tumor growth by endohedral metallofullerenol nanoparticles optimized as reactive oxygen species scavenger[J]. MOLECULAR PHARMACOLOGY,2008,74(4):1132-1140. |
| APA | Yin, JJ.,Lao, F.,孟洁.,赵宇亮.,邢更妹.,...&Liang, XJ.(2008).Inhibition of tumor growth by endohedral metallofullerenol nanoparticles optimized as reactive oxygen species scavenger.MOLECULAR PHARMACOLOGY,74(4),1132-1140. |
| MLA | Yin, JJ,et al."Inhibition of tumor growth by endohedral metallofullerenol nanoparticles optimized as reactive oxygen species scavenger".MOLECULAR PHARMACOLOGY 74.4(2008):1132-1140. |
入库方式： OAI收割
来源：高能物理研究所
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