[Gd@C-82(OH)(22)](n) Nanoparticles Induce Dendritic Cell Maturation and Activate Th1 Immune Responses
文献类型：期刊论文
| 作者 | Yang, D; Zhao YL(赵宇亮) ; Xing GM(邢更妹); Zhao, YL; Guo, H; Li, YN; Tewary, P; Xing, GM; Hou, W; Oppenheim, JJ
|
| 刊名 | ACS NANO
 |
| 出版日期 | 2010 |
| 卷号 | 4期号:2页码:1178-1186 |
| 关键词 | nanomedicine fullerene dendritic cells activation Th1 polarization |
| 通讯作者 | [Yang, De ; Guo, Hua ; Hou, Wei ; Zhang, Ning] Tianjin Med Univ, Res Ctr Basic Med Sci, Canc Inst & Hosp, Key Lab Breast Canc Res,Minist Educ, Tianjin 300060, Peoples R China ; [Yang, De ; Li, Yana ; Tewary, Poonam ; Oppenheim, Joost J.] NCI, Basic Res Program, SAIC Frederick Inc,Ctr Canc Res, Lab Mol Immunoregulat,Canc & Inflammat Program, Frederick, MD 21702 USA ; [Zhao, Yuliang ; Xing, Gengmei] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China |
| 英文摘要 | Dendritic cells play a pivotal role in host immune defense, such as elimination of foreign pathogen and inhibition of tumorigenesis. In this paper, we report that [Gd@C-82(OH)(22)](n) could induce phenotypic maturation of. dendritic cells by stimulating DC production of cytokines including IL-12p70, upregulating DC co-stimulatory (CD80, CD83, and CD86) and MHC (HLA-A,B,C and HLA-DR) molecules, and switching DCs from a CCL5-responsive to a CCL19-responsive phenotype. We found that [Gd@C-82(OH)(22)](n) can induce dendritic cells to become functionally mature as illustrated by their capacity to activate allogeneic T cells. Mice immunized with ovalbumin in the presence of [Gd@C-82(OH)(22)](n) exhibit enhanced ovalbumin-specific Th1-polarized immune response as evidenced by the predominantly increased production of IFN gamma, IL-1 beta, and IL-2. The [Gd@C-82(OH)(22)](n) nanoparticle is a potent activator of dendritic cells and Th1 immune responses. These new findings also provide a rational understanding of the potent anticancer activities of [Gd@C-82(OH)(22)](n) nanoparticles reported previously. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000274635800074 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/239146]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_加速器中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Yang, D,Zhao YL,Xing GM,et al. [Gd@C-82(OH)(22)](n) Nanoparticles Induce Dendritic Cell Maturation and Activate Th1 Immune Responses[J]. ACS NANO,2010,4(2):1178-1186. |
| APA | Yang, D.,赵宇亮.,邢更妹.,Zhao, YL.,Guo, H.,...&Zhang, N.(2010).[Gd@C-82(OH)(22)](n) Nanoparticles Induce Dendritic Cell Maturation and Activate Th1 Immune Responses.ACS NANO,4(2),1178-1186. |
| MLA | Yang, D,et al."[Gd@C-82(OH)(22)](n) Nanoparticles Induce Dendritic Cell Maturation and Activate Th1 Immune Responses".ACS NANO 4.2(2010):1178-1186. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。