Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis
文献类型：期刊论文
| 作者 | Zhang J(张杰); Chen Q(陈启); Liu NQ(刘年庆); Li FL(李福亮); Zhang, J ; Liu, Q; Chen, Q; Liu, NQ; Li, FL; Lu, ZB
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| 刊名 | FASEB JOURNAL
 |
| 出版日期 | 2006 |
| 卷号 | 20期号:8页码:1212-+ |
| 关键词 | Alzheimer's disease A beta copper |
| 通讯作者 | Acad Sinica, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China ; Salk Inst Biol Studies, La Jolla, CA 92037 USA ; Acad Sinica, Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100101, Peoples R China ; Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100037, Peoples R China ; Acad Sinica, Inst High Energy Phys, Sychrotron Radiat Lab, Beijing 100101, Peoples R China ; Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 英文摘要 | Nicotine reduces beta-amyloidosis and has a beneficial effect against Alzheimer's disease (AD), but the underlying mechanism is not clear. The abnormal interactions of beta-amyloid (A beta) with metal ions such as copper and zinc are implicated in the process of A beta deposition in AD brains. In the present study, we investigated the effect of nicotine on metal homeostasis in the hippocampus and cortex of APP(V717I) ( London mutant form of APP) transgenic mice. A significant reduction in the metal contents of copper and zinc in senile plaques and neuropil is observed after nicotine treatment. The densities of copper and zinc distributions in a subfield of the hippocampus CA1 region are also reduced after nicotine treatment. We further studied the mechanism of nicotine-mediated effect on metal homeostasis by using SH-SY5Y cells overexpressing the Swedish mutant form of human APP (APPsw). Nicotine treatment decreases the intracellular copper concentration and attenuates A beta-mediated neurotoxicity facilitated by the addition of copper, and these effects are independent of the activation of nicotinic acetylcholine-receptor. These data suggest that the effect of nicotine on reducing beta-amyloidosis is partly mediated by regulating metal homeostasis. |
| 学科主题 | Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other Topics; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biology ; Cell Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000240210300029 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/239189]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhang J,Chen Q,Liu NQ,et al. Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis[J]. FASEB JOURNAL,2006,20(8):1212-+. |
| APA | 张杰.,陈启.,刘年庆.,李福亮.,Zhang, J.,...&Zhao, BL.(2006).Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis.FASEB JOURNAL,20(8),1212-+. |
| MLA | 张杰,et al."Nicotine attenuates beta-amyloid-induced neurotoxicity by regulating metal homeostasis".FASEB JOURNAL 20.8(2006):1212-+. |
入库方式： OAI收割
来源：高能物理研究所
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