Protective role of 3-nitrotyrosine against gamma radiation-induced DNA strand breaks: A comparison study with tyrosine
文献类型：期刊论文
| 作者 | Shi WQ(石伟群) ; Shi, WQ; Ni, MN; Kong, FQ; Sui, L; Hu, J; Xu, DD; Li, YM; Xu DD(徐殿斗)
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| 刊名 | RADIATION PHYSICS AND CHEMISTRY
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| 出版日期 | 2008 |
| 卷号 | 77期号:10-12页码:1290-1293 |
| 关键词 | 3-nitrotyrosine gamma irradiation PBR322 DNA strand breaks |
| 通讯作者 | [Shi, Wei-Qun ; Xu, Dian-Dou] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Ni, Mei-Nan ; Kong, Fu-Quan ; Sui, Li] China Inst Atom Energy, Dept Nucl Phys, Beijing, Peoples R China ; [Hu, Jia ; Li, Yan-Mei] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorous Chem & Chem Biol, Beijing 100084, Peoples R China |
| 英文摘要 | 3-Nitrotyrosine(3-NY) has been reported as a potential source of reactive oxygen species (ROSs). In this work, plasmid pBR322 DNA was irradiated by gamma rays in aqueous solution in presence and absence of 3-NY, DNA strand breaks were analyzed by neutral electrophoresis followed by quantification with image analysis software. It was found that the presence of 3-NY could effectively reduce radiation-induced DNA strand breaks. A side-by-side comparison was performed between 3-NY and tyrosine, the results showed that the protective role 3-NY was comparable with tyrosine, which might imply that protein tyrosine nitration might not significantly decrease its ability as a free radical scavenger. (C) 2008 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry; Nuclear Science & Technology; Physics |
| 类目[WOS] | Chemistry, Physical ; Nuclear Science & Technology ; Physics, Atomic, Molecular & Chemical |
| 研究领域[WOS] | Chemistry ; Nuclear Science & Technology ; Physics |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259798400033 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/239258]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Shi WQ,Shi, WQ,Ni, MN,et al. Protective role of 3-nitrotyrosine against gamma radiation-induced DNA strand breaks: A comparison study with tyrosine[J]. RADIATION PHYSICS AND CHEMISTRY,2008,77(10-12):1290-1293. |
| APA | 石伟群.,Shi, WQ.,Ni, MN.,Kong, FQ.,Sui, L.,...&徐殿斗.(2008).Protective role of 3-nitrotyrosine against gamma radiation-induced DNA strand breaks: A comparison study with tyrosine.RADIATION PHYSICS AND CHEMISTRY,77(10-12),1290-1293. |
| MLA | 石伟群,et al."Protective role of 3-nitrotyrosine against gamma radiation-induced DNA strand breaks: A comparison study with tyrosine".RADIATION PHYSICS AND CHEMISTRY 77.10-12(2008):1290-1293. |
入库方式： OAI收割
来源：高能物理研究所
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