Transport and absorption of chiral metal complexes d-[Co(EDTA)] and l-[Co(EDTA)](-) across Caco-2 cell monolayers
文献类型：期刊论文
| 作者 | Mu, YP; Wu, G ; Qiao, XW; Gao, YX; Zhou, LS; He, YL; Gao YX(高愈希)
|
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2008 |
| 卷号 | 29期号:7页码:1321-1324 |
| 关键词 | chirality metal complex Caco-2 cell monolayer transpot absorption |
| 通讯作者 | [Mu Yong-Ping ; Wu Gang ; Zhou Li-She] Baotou Med Coll, Dept Biochem & Mol Biol, Baotou 014010, Peoples R China ; [Qiao Xiu-Wen] Shihezi Univ, Sch Chem & Chem Engn, Shihezi 832002, Peoples R China ; [Gao Yu-Xi] Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Wu Gang ; He Yan-Ling] Baotou Med Coll, Res Inst Trace Element Organism, Baotou 014010, Peoples R China |
| 英文摘要 | The trasport rate of chiral complexes d-[Co(EDTA)](-) and 1-[Co(EDTA)](-) across Caco-2 cell monolayers were measured by the kinetics method. The studies discover that there is an obvious difference about the trasport rate of d-[Co(EDTA)](-) and 1-[Co(EDTA)](-) when they get across Caco-2 cell monolayers because of the chiral difference of the metal complexes. The results show that there is a chiral selectivity when chiral metal complexes were transported and absorbed across Caco-2 cell monolayers and imply that intestine would selectively absorb drugs of chiral metal complexes. The trasport rate of d-[Co(EDTA)](-) and l-[Co(EDTA)](-) passing through Caco-2 cell monolayers depends on the grads of the complexes concentration, it is shown that their transport model is as simple diffuse when they were transported and absorbed through Caco-2 cell monolayers. |
| 学科主题 | Chemistry |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000258092900007 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/239277]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_加速器中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Mu, YP,Wu, G,Qiao, XW,et al. Transport and absorption of chiral metal complexes d-[Co(EDTA)] and l-[Co(EDTA)](-) across Caco-2 cell monolayers[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2008,29(7):1321-1324. |
| APA | Mu, YP.,Wu, G.,Qiao, XW.,Gao, YX.,Zhou, LS.,...&高愈希.(2008).Transport and absorption of chiral metal complexes d-[Co(EDTA)] and l-[Co(EDTA)](-) across Caco-2 cell monolayers.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,29(7),1321-1324. |
| MLA | Mu, YP,et al."Transport and absorption of chiral metal complexes d-[Co(EDTA)] and l-[Co(EDTA)](-) across Caco-2 cell monolayers".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 29.7(2008):1321-1324. |
入库方式： OAI收割
来源：高能物理研究所
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