Studies on anti-tumor and antimetastatic activities of fullerenol in a mouse breast cancer model
文献类型：期刊论文
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| 作者 | Jiao, F; Liu, Y; Qu, Y; Li, W; Zhou, GQ; Ge, CC; Li, YF; Sun, BY ; Chen, CY; Li W(李炜)
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| 刊名 | CARBON
 ; CARBON
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| 出版日期 | 2010 ; 2010 |
| 卷号 | 48期号:8页码:2231-2243 |
| DOI | 10.1016/j.carbon.2010.02.032 |
| 通讯作者 | [Jiao, Fang ; Liu, Ying ; Qu, Ying ; Li, Wei ; Zhou, Guoqiang ; Ge, Cuicui ; Li, Yufeng ; Sun, Baoyun ; Chen, Chunying] Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Beijing 100049, Peoples R China ; [Jiao, Fang ; Liu, Ying ; Qu, Ying ; Li, Wei ; Zhou, Guoqiang ; Ge, Cuicui ; Li, Yufeng ; Sun, Baoyun ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Jiao, Fang ; Li, Wei ; Zhou, Guoqiang ; Ge, Cuicui ; Li, Yufeng ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Jiao, Fang ; Liu, Ying ; Qu, Ying ; Li, Wei ; Zhou, Guoqiang ; Ge, Cuicui ; Li, Yufeng ; Sun, Baoyun ; Chen, Chunying] Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Beijing 100049, Peoples R China ; [Jiao, Fang ; Liu, Ying ; Qu, Ying ; Li, Wei ; Zhou, Guoqiang ; Ge, Cuicui ; Li, Yufeng ; Sun, Baoyun ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Jiao, Fang ; Li, Wei ; Zhou, Guoqiang ; Ge, Cuicui ; Li, Yufeng ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | The purpose was to examine the anti-tumor and antimetastatic activities of fullerenol and their related mechanisms. Thirty EMT-6 tumor-bearing mice were injected intraperitoneally with 0.1 ml saline or 0.1 ml saline containing fullerenol C(60)(OH)(20) (0.08 and 0.4 mg/ml) daily for 16 days. Using tumor tissues, we investigated imbalances in the oxidative defense system and the expression of several angiogenesis factors. C(60)(OH)(20) exhibits anti-tumor and antimetastatic activities in EMT-6 breast cancer metastasis model. Treatment with C(60)(OH)(20) was found to modulate oxidative stress significantly. The expression of several angiogenesis factors was reduced in tumor tissues after treatment with fullerenol. Importantly, CD31 (also known as PECAM-1, platelet endothelial cell adhesion molecule) expression and vessel density were markedly reduced in tumors from fullerenol-treated mice compared with controls. Modulation of oxidative stress in tumor tissues, inhibition of the formation of angiogenesis factors, and subsequent reduction in tumor vessel density and the nutrient supply to tumor cells could be important mechanisms by which fullerenol aggregates inhibit tumor growth and suppress carcinoma metastasis in vivo. (C) 2010 Elsevier Ltd. All rights reserved.; The purpose was to examine the anti-tumor and antimetastatic activities of fullerenol and their related mechanisms. Thirty EMT-6 tumor-bearing mice were injected intraperitoneally with 0.1 ml saline or 0.1 ml saline containing fullerenol C(60)(OH)(20) (0.08 and 0.4 mg/ml) daily for 16 days. Using tumor tissues, we investigated imbalances in the oxidative defense system and the expression of several angiogenesis factors. C(60)(OH)(20) exhibits anti-tumor and antimetastatic activities in EMT-6 breast cancer metastasis model. Treatment with C(60)(OH)(20) was found to modulate oxidative stress significantly. The expression of several angiogenesis factors was reduced in tumor tissues after treatment with fullerenol. Importantly, CD31 (also known as PECAM-1, platelet endothelial cell adhesion molecule) expression and vessel density were markedly reduced in tumors from fullerenol-treated mice compared with controls. Modulation of oxidative stress in tumor tissues, inhibition of the formation of angiogenesis factors, and subsequent reduction in tumor vessel density and the nutrient supply to tumor cells could be important mechanisms by which fullerenol aggregates inhibit tumor growth and suppress carcinoma metastasis in vivo. (C) 2010 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry; Materials Science ; Chemistry; Materials Science |
| 类目[WOS] | Chemistry, Physical ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Chemistry ; Materials Science |
| URL标识 | 查看原文 |
| WOS研究方向 | Chemistry ; Materials Science |
| 原文出处 | SCI |
| 语种 | 英语 ; 英语 |
| WOS记录号 | WOS:000277780500012 ; WOS:000277780500012 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/239696]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Jiao, F,Liu, Y,Qu, Y,et al. Studies on anti-tumor and antimetastatic activities of fullerenol in a mouse breast cancer model, Studies on anti-tumor and antimetastatic activities of fullerenol in a mouse breast cancer model[J]. CARBON, CARBON,2010, 2010,48, 48(8):2231-2243, 2231-2243. |
| APA | Jiao, F.,Liu, Y.,Qu, Y.,Li, W.,Zhou, GQ.,...&陈春英.(2010).Studies on anti-tumor and antimetastatic activities of fullerenol in a mouse breast cancer model.CARBON,48(8),2231-2243. |
| MLA | Jiao, F,et al."Studies on anti-tumor and antimetastatic activities of fullerenol in a mouse breast cancer model".CARBON 48.8(2010):2231-2243. |
入库方式： OAI收割
来源：高能物理研究所
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