An Anti-Tumor Nanoparticle, [Gd@C-82(OH)(22)]n, Induces Macrophage Activation
文献类型：期刊论文
| 作者 | Wang, BB ; Yang, D; Sun BY(孙宝云); Sun, BY; Wei, XY; Guo, H; Liu, XL; Ying, GG; Niu, RF; Zhang, N
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| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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| 出版日期 | 2011 |
| 卷号 | 11期号:3页码:2321-2329 |
| 关键词 | Nanoparticle [Gd@C-82(OH)(22)](n) Macrophage Immune Response Activation |
| 通讯作者 | [Wang, Bingbing ; Wei, Xiyin ; Guo, Hua ; Liu, Xiaoli ; Ying, Guoguang ; Zhang, Ning ; Ma, Yongjie] Tianjin Med Univ, Canc Inst & Hosp, Cent Lab Oncol Dept,Res Ctr Basic Med Sci, Minst Educ,Key Lab Breast Canc Prevent & Therapy, Tianjin 300060, Peoples R China ; [Yang, De] Ctr Canc Res & Basic Res Program, Mol Immunoregulat Lab, Frederick, MD 21702 USA ; [Sun, Baoyun] Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Niu, Ruifang] Tianjin Med Univ, Canc Inst & Hosp, Publ Lab, Tianjin 300060, Peoples R China |
| 英文摘要 | [Gd@C-82(OH)(22)](n), a fullerene-based nanoparticle, exhibits potent anti-tumor effects in mouse tumor-bearing models without detectable toxicity and the pathological studies revealed a massive infiltration of leukocytes in the residual tumors of [Gd@C-82(OH)(22)](n)-treated mice. We report here that [Gd@C-82(OH)(22)](n) promotes macrophages secreting pro-inflammatory cytokines IL-6 and TNF-alpha, enhances the expression of MHC-II and costimulatory molecules such as CD40 and CD54, increases endocytosis and cell adhesion. Furthermore, [Gd@C-82(OH)(22)](n)-treated macrophages,n became functionally activated as illustrated by their capacity to activate allogeneic T cells. Taken together, our results indicate that [Gd@C-82(OH)(22)](n) nanoparticle is a potent activator of, macrophages, which may in part account for its potent anti-tumor effect. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 类目[WOS] | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000288102300072 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/239716]  |
| 专题 | 高能物理研究所_核技术应用研究中心 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wang, BB,Yang, D,Sun BY,et al. An Anti-Tumor Nanoparticle, [Gd@C-82(OH)(22)]n, Induces Macrophage Activation[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2011,11(3):2321-2329. |
| APA | Wang, BB.,Yang, D.,孙宝云.,Sun, BY.,Wei, XY.,...&Ma, YJ.(2011).An Anti-Tumor Nanoparticle, [Gd@C-82(OH)(22)]n, Induces Macrophage Activation.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,11(3),2321-2329. |
| MLA | Wang, BB,et al."An Anti-Tumor Nanoparticle, [Gd@C-82(OH)(22)]n, Induces Macrophage Activation".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 11.3(2011):2321-2329. |
入库方式： OAI收割
来源：高能物理研究所
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