Fullerene Nanoparticles Selectively Enter Oxidation-Damaged Cerebral Microvessel Endothelial Cells and Inhibit JNK-Related Apoptosis
文献类型：期刊论文
| 作者 | Lao, F; Chen, L ; Li, W; Ge, CC; Qu, Y; Sun, QM; Zhao, YL; Han, D; Chen, CY; Zhao YL(赵宇亮)
|
| 刊名 | ACS NANO
 |
| 出版日期 | 2009 |
| 卷号 | 3期号:11页码:3358-3368 |
| 关键词 | C(60)(C(COOH)(2))(2) microvessel endothelial cells oxidative injury apoptosis JNK pathway |
| 通讯作者 | [Lao, Fang ; Chen, Long ; Qu, Ying ; Sun, Quanmei ; Han, Dong ; Chen, Chunying] Natl Ctr Nanosci & Technol NCNST, Beijing 100190, Peoples R China ; [Lao, Fang ; Chen, Long ; Li, Wei ; Ge, Cuicui ; Qu, Ying ; Sun, Quanmei ; Zhao, Yuliang ; Han, Dong ; Chen, Chunying] Chinese Acad Sci, NCNST, IHEP, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China |
| 英文摘要 | There is a dearth in fundamental cellular-level understanding of how nanoparticles interact with the cells of the blood brain barrier (BBB), particularly under the oxidative environment. The apoptosis of cerebral microvessel enclothelial cells (CMECs) induced by oxidative stress injury plays a key role in the dysfunction of BBB. By use of CMECs as an in vitro BBB model, we show for the first time that C(60)(C(COOH)(2))(2) nanoparticles can selectively enter oxidized CMECs rather than normal cells, and maintain CMECs integrity by attenuating H(2)O(2)-induced F-actin depolymerization via the observation of several state-of-the art microscopic techniques. Additionally, we have found that C(60)(C(COOH)(2))(2) nanoparticles greatly inhibit the apoptosis of CMECs induced by H(2)O(2), which is related to their modulation of the JNK pathway. C(60)(C(COOH)(2))(2) nanoparticles can regulate several downstream signaling events related to the JNK pathway, including reduction of JNK phosphorylation, activation of activator protein 1 (AP-1) and caspase-3, and inhibition of polyADP-ribose polymerase (PARP) cleavage and mitochondrial cytochrome c release. Our results indicate that C(60)(C(COOH)(2))(2) nanoparticles possess a novel ability of selectively entering oxidation-damaged cerebral enclothelial cells rather than normal enclothelial cells and then protecting them from apoptosis. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000271951200006 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/239897]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_理论物理室 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Lao, F,Chen, L,Li, W,et al. Fullerene Nanoparticles Selectively Enter Oxidation-Damaged Cerebral Microvessel Endothelial Cells and Inhibit JNK-Related Apoptosis[J]. ACS NANO,2009,3(11):3358-3368. |
| APA | Lao, F.,Chen, L.,Li, W.,Ge, CC.,Qu, Y.,...&赵宇亮.(2009).Fullerene Nanoparticles Selectively Enter Oxidation-Damaged Cerebral Microvessel Endothelial Cells and Inhibit JNK-Related Apoptosis.ACS NANO,3(11),3358-3368. |
| MLA | Lao, F,et al."Fullerene Nanoparticles Selectively Enter Oxidation-Damaged Cerebral Microvessel Endothelial Cells and Inhibit JNK-Related Apoptosis".ACS NANO 3.11(2009):3358-3368. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。