Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents
文献类型：期刊论文
| 作者 | Miao, QH; Xu, DX; Wang, Z; Xu, L ; Wang, TW; Wu, Y; Lovejoy, DB; Kalinowski, DS; Richardson, DR; Nie, GJ
|
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2010 |
| 卷号 | 31期号:28页码:7364-7375 |
| 关键词 | Controlled drug release Cytotoxicity Drug delivery Nanoparticle |
| 通讯作者 | [Lovejoy, David B. ; Kalinowski, Danuta S. ; Richardson, Des R.] Univ Sydney, Dept Pathol, Sydney, NSW 2006, Australia ; [Lovejoy, David B. ; Kalinowski, Danuta S. ; Richardson, Des R.] Univ Sydney, Bosch Inst, Sydney, NSW 2006, Australia ; [Miao, Qinghua ; Xu, Dongxue ; Wang, Tiewei ; Wu, Yan ; Nie, Guangjun ; Zhao, Yuliang] CAS, Key Lab Biol Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing, Peoples R China ; [Miao, Qinghua ; Xu, Dongxue ; Wang, Zhi ; Xu, Li] Jilin Univ, Minist Educ, Key Lab Mol Enzymol & Engn, Changchun 130023, Peoples R China ; [Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing, Peoples R China |
| 英文摘要 | In this investigation, we have designed and synthesized an amphiphilic co-polymer with hyper-branched poly(amine-ester) and polylactide (HPAE-co-PLA) to generate nanoparticles (NPs). These have been used to encapsulate a highly active hydrophobic anti-tumor agent, 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone (Bp4eT). Encapsulation in NPs was done in an effort to increase the anti-tumor activity of this agent by facilitating its delivery to tumor cells. We have also examined and optimized the formulation parameters of the NPs that alter their drug-loading capacity and their physical, chemical and biological properties. The resulting NPs exhibited high Bp4eT-loading capacity and substantial stability in aqueous solution. In vitro drug release studies demonstrated a controlled drug release profile with increased release at acidic pH. Anti-tumor proliferation assays showed that both free drug and drug-encapsulated NPs markedly inhibited tumor cell proliferation in a time- and concentration-dependent manner. Direct microscopic observation revealed that the fluorescent NPs were taken up by cells and localized, in part, in organelles consistent with lysosomes. These results demonstrate a feasible application of the amphiphilic hyper-branched co-polymer, HPAE-co-PLA, as nanocarriers for intracellular delivery of potent anti-tumor agents. (C) 2010 Elsevier Ltd. All rights reserved. |
| 学科主题 | Engineering; Materials Science |
| 类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
| 研究领域[WOS] | Engineering ; Materials Science |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000281183000016 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/240113]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Miao, QH,Xu, DX,Wang, Z,et al. Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents[J]. BIOMATERIALS,2010,31(28):7364-7375. |
| APA | Miao, QH.,Xu, DX.,Wang, Z.,Xu, L.,Wang, TW.,...&赵宇亮.(2010).Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents.BIOMATERIALS,31(28),7364-7375. |
| MLA | Miao, QH,et al."Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents".BIOMATERIALS 31.28(2010):7364-7375. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。