Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis
文献类型：期刊论文
| 作者 | Liang, XJ; Meng H(孟幻); Meng J(孟洁); Zhao YL(赵宇亮) ; Gao XY(高学云); Sun BY(孙宝云); Xing GM(邢更妹); Meng, H; Wang, YZ; He, HY
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| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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| 出版日期 | 2010 |
| 卷号 | 107期号:16页码:7449-7454 |
| 关键词 | drug resistance nanomedicine nanoimaging chemotherapy nanopharmaceutical |
| 通讯作者 | [Liang, Xing-Jie ; Wang, Yingze ; He, Haiyong ; Meng, Jie ; Lu, Juan ; Chen, Chunying ; Wu, Yan] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China ; [Meng, Huan ; Meng, Jie ; Zhao, Yuliang ; Gao, Xueyun ; Sun, Baoyun ; Xing, Genmei] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Wang, Paul C.] Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA ; [Shen, Dingwu ; Gottesman, Michael M.] NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA ; [Yin, Jun-jie] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA ; [Jia, Lee] NCI, Dev Therapeut Program, Div Canc Treatment & Diag, NIH, Bethesda, MD 20892 USA |
| 英文摘要 | Cisplatin is a chemotherapeutic drug commonly used in clinics. However, acquired resistance confines its application in chemotherapeutics. To overcome the acquired resistance to cisplatin, it is reasoned, based on our previous findings of mediation of cellular responses by [Gd@C(82)(OH)(22)](n) nanoparticles, that [Gd@C(82)(OH)(22)](n) may reverse tumor resistance to cisplatin by reactivating the impaired endocytosis of cisplatin-resistant human prostate cancer (CP-r) cells. Here we report that exposure of the CP-r PC-3-luc cells to cisplatin in the presence of nontoxic [Gd@C(82)(OH)(22)](n) not only decreased the number of surviving CP-r cells but also inhibited growth of the CP-r tumors in athymic nude mice as measured by both optical and MRI. Labeling the CP-r PC-3 cells with transferrin, an endocytotic marker, demonstrated that pretreatment of the CP-r PC-3-luc cells with [Gd@C(82)(OH)(22)](n) enhanced intracellular accumulation of cisplatin and formation of cisplatin-DNA adducts by restoring the defective endocytosis of the CP-r cancer cells. The results suggest that [Gd@C(82)(OH)(22)](n) nanoparticles overcome tumor resistance to cisplatin by increasing its intracellular accumulation through the mechanism of restoring defective endocytosis. The technology can be extended to other challenges related to multidrug resistance often found in cancer treatments. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000276892300062 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/240118]  |
| 专题 | 中国科学院高能物理研究所_中国散裂中子源 高能物理研究所_实验物理中心 高能物理研究所_加速器中心 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Liang, XJ,Meng H,Meng J,et al. Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2010,107(16):7449-7454. |
| APA | Liang, XJ.,孟幻.,孟洁.,赵宇亮.,高学云.,...&Jia, L.(2010).Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(16),7449-7454. |
| MLA | Liang, XJ,et al."Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.16(2010):7449-7454. |
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来源：高能物理研究所
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