In Vitro Cytotoxicity of Transparent Yellow Iron Oxide Nanoparticles on Human Glioma Cells
文献类型：期刊论文
| 作者 | Wang Y(王云) ; Zhu MT(朱墨桃); Wang B(汪冰); Wang M(王萌); Wang HJ(王华建); Ou YH(欧阳宏); Feng WY(丰伟悦); Yun, W; Zhu, MT; Bing, W
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| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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| 出版日期 | 2010 |
| 卷号 | 10期号:12页码:8550-8555 |
| 关键词 | Iron Oxide Yellow Nanoparticles Cytotoxicity Human Glioma Cell |
| 通讯作者 | [Yun Wang ; Zhu, Mo-Tao ; Bing Wang ; Meng Wang ; Wang, Hua-jian ; Hong OuYang ; Feng, Wei-Yue] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Yun Wang ; Zhu, Mo-Tao ; Bing Wang ; Meng Wang ; Wang, Hua-jian ; Hong OuYang ; Feng, Wei-Yue] Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Yun Wang ; Zhu, Mo-Tao ; Wang, Hua-jian] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 英文摘要 | With rapid development of nanotechnology, concerns about the possible adverse health effects on human beings by using nanomaterials have been raised. Transparent yellow iron oxide (alpha-FeOOH) nanoparticles have been widely used in paints, plastic, rubber, building materials, papermaking, food products and pharmaceutical industry, thus the potential health implications by the exposure should be considered. The purpose of this study is to assess the cytotoxicity of transparent yellow iron oxide nanoparticles on U251 human glioma cells. The alpha-FeOOH nanoparticles are in clubbed shapes with 9 nm in diameter and 43 nm long. The specific surface area is 115.3 m(2)/g. After physicochemical characterization of the nanoparticles, U251 cells were exposed to alpha-FeOOH at the doses of 0, 3.75, 15, 60 and 120 mu g/mL. The results showed that the alpha-FeOOH nanoparticles reduced the cell viability and induced necrosis and apoptosis in U251 cells. In addition, nanoparticle exposure significantly increased the levels of superoxide anion and nitric oxide in a dose-dependent fashion in the cells. Our results suggest that exposure to alpha-FeOOH nanoparticles induce significant free radical formation and cytotoxic effects. The large surface area that induced high surface reactivity may play an important role in the cytotoxic effect of alpha-FeOOH nanoparticles. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 类目[WOS] | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000283621400092 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/240141]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_加速器中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wang Y,Zhu MT,Wang B,et al. In Vitro Cytotoxicity of Transparent Yellow Iron Oxide Nanoparticles on Human Glioma Cells[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(12):8550-8555. |
| APA | 王云.,朱墨桃.,汪冰.,王萌.,王华建.,...&Feng, WY.(2010).In Vitro Cytotoxicity of Transparent Yellow Iron Oxide Nanoparticles on Human Glioma Cells.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(12),8550-8555. |
| MLA | 王云,et al."In Vitro Cytotoxicity of Transparent Yellow Iron Oxide Nanoparticles on Human Glioma Cells".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.12(2010):8550-8555. |
入库方式： OAI收割
来源：高能物理研究所
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