Subcellular Distribution of Polyhydroxylated Metallofullerene Gd@C-82(OH)(22) in Different Tissues of Tumor-Bearing Mice
文献类型：期刊论文
| 作者 | Zhou GQ(周国庆); Li YF(李玉锋) ; Liu Y(刘颖); Ge CC(葛翠翠); Li W(李炜); Sun BY(孙宝云); Li B(李柏); Gao YX(高愈希); Chen CY(陈春英); Zhou, GQ
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| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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| 出版日期 | 2010 |
| 卷号 | 10期号:12页码:8597-8602 |
| 关键词 | Subcellular Distribution Gd@C-82(OH)(22) Nanoparticle |
| 通讯作者 | [Sun, Baoyun] Chinese Acad Sci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100864, Peoples R China ; Chinese Acad Sci, Key Lab Nucl Analyt Tech, Inst High Energy Phys, Beijing 100864, Peoples R China |
| 英文摘要 | Endohedral metallofullerenes have unique chemical and physical properties that are essential for biomedical applications. They can be used as a radiotracer in magnetic resonance and X-ray imaging (MRI and XRI). Polyhydroxylated metallofullerene Gd@C-82(OH)(x) has been studied as a new high efficient contrast agents for MRI and has also shown high efficiency for antitumor growth. Previous studies have shown that Gd@C-82(OH)(22) mainly accumulated in bone, pancreas, liver and kidney after intraperitoneal administration. However, whether the nanoparticles can enter into cells and the site of their potential action remains unclear. In this work, the distribution patterns of Gd@C-82(OH)(22) in subcellular compartments were studied using the techniques of differential centrifugation and ICP-MS analysis. The results indicate that the Gd@C-82(OH)(22) can enter into cells and the subcellular distribution patterns are significantly different from that of GdCl3. GdCl3 has much higher bioavailability for mice than Gd@C-82(OH)22. Therefore, the present data suggest that Gd@C-82(OH)(22) in living systems may be not decomposed to release free Gd3+ ion and may be metabolized as a pristine carbon cage. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 类目[WOS] | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000283621400098 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/240144]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_实验物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhou GQ,Li YF,Liu Y,et al. Subcellular Distribution of Polyhydroxylated Metallofullerene Gd@C-82(OH)(22) in Different Tissues of Tumor-Bearing Mice[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(12):8597-8602. |
| APA | 周国庆.,李玉锋.,刘颖.,葛翠翠.,李炜.,...&Chen, CY.(2010).Subcellular Distribution of Polyhydroxylated Metallofullerene Gd@C-82(OH)(22) in Different Tissues of Tumor-Bearing Mice.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(12),8597-8602. |
| MLA | 周国庆,et al."Subcellular Distribution of Polyhydroxylated Metallofullerene Gd@C-82(OH)(22) in Different Tissues of Tumor-Bearing Mice".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.12(2010):8597-8602. |
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来源：高能物理研究所
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