EXAFS study on the local atomic structures around iron in glycosylated haemoglobin
文献类型：期刊论文
| 作者 | Wu ZH(吴忠华) ; Guo L(郭林); Wu, ZH; Benfield, RE; Wang, YS; Guo, L; Tan, MG; Zhang, HD; Ge, YX; Grandjean, D
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| 刊名 | PHYSICS IN MEDICINE AND BIOLOGY
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| 出版日期 | 2001 |
| 卷号 | 46期号:3页码:N71-N77 |
| 通讯作者 | Chinese Acad Sci, Inst High Energy Phys, BSRL, Beijing 100039, Peoples R China ; Univ Kent, Ctr Mat Res, Sch Phys Sci, Canterbury CT2 7NR, Kent, England ; Chinese Acad Sci, Shanghai Inst Nucl Res, Shanghai 201800, Peoples R China ; First Peoples Hosp Shanghai, Shanghai 200080, Peoples R China |
| 英文摘要 | Samples with 5.1%, 9.8% and 15.3% HbA1c were extracted from normal subjects and patients with slight and serious diabetes respectively. Extended x-ray absorption fine structure spectra of Fe K absorption were collected at the EXAFS experimental station of the Beijing Synchrotron Radiation Facility. The step-by-step fluorescent mode was employed with a count time of 10 s per point. Several independent scans were averaged to eliminate the statistical noise. Reference backscattering amplitudes and phaseshifts were calculated using the curve wave theory (FEFF code) of EXAFS. Apart from the nitrogen neighbours around the central iron atom, oxygen neighbours are also found. The Fe-N bond length increases by about 0.02 Angstrom for the sample with 15.3% HbA1c compared with the others, but the Fe-O bond length is almost unchanged. With increasing of HbA1c concentration, the content of Hb increases and the content of HbO(2) decreases. This demonstrates that the glycosylation of haemoglobin will decrease its ability to carry oxygen. |
| 学科主题 | Engineering; Radiology, Nuclear Medicine & Medical Imaging |
| 类目[WOS] | Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Engineering ; Radiology, Nuclear Medicine & Medical Imaging |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000167520400024 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/240315]  |
| 专题 | 高能物理研究所_多学科研究中心 高能物理研究所_粒子天体物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wu ZH,Guo L,Wu, ZH,et al. EXAFS study on the local atomic structures around iron in glycosylated haemoglobin[J]. PHYSICS IN MEDICINE AND BIOLOGY,2001,46(3):N71-N77. |
| APA | 吴忠华.,郭林.,Wu, ZH.,Benfield, RE.,Wang, YS.,...&Grandjean, D.(2001).EXAFS study on the local atomic structures around iron in glycosylated haemoglobin.PHYSICS IN MEDICINE AND BIOLOGY,46(3),N71-N77. |
| MLA | 吴忠华,et al."EXAFS study on the local atomic structures around iron in glycosylated haemoglobin".PHYSICS IN MEDICINE AND BIOLOGY 46.3(2001):N71-N77. |
入库方式： OAI收割
来源：高能物理研究所
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