The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency
文献类型：期刊论文
| 作者 | Liu NQ(刘年庆); Xu Q(徐清) ; Hou XL(侯小琳); Liu PS(刘平生); Chai ZF(柴之芳); Liu, NQ; Xu, Q; Hou, XL; Liu, PS; Chai, ZF
|
| 刊名 | BRAIN RESEARCH BULLETIN
 |
| 出版日期 | 2001 |
| 卷号 | 55期号:2页码:309-312 |
| 关键词 | nuclear analytical techniques trace elements metals cretinism |
| 通讯作者 | Acad Sinica, Inst High Energy Phys, Lab Nucl Analyt Tech, Beijing 100080, Peoples R China ; Peking Union Med Coll Hosp, Dept Nucl Med, Beijing, Peoples R China |
| 英文摘要 | Cretinism is a disease characterized by neurological defects associated with severe iodine deficiency. In a rat model of severe iodine deficiency, we investigated the distribution pattern of trace elements (Iodine [1], selenium [Se], and bromine [Br] in brain tissue samples; potassium [K], calcium [Ca], manganese [Mn], iron [Fe], copper [Cu], zinc [Zn], rubidium [Rb], and lead [Pb] in erythrocytes) after supplementing the rats with I and/or Se. Neutron activation analysis, proton induced x-ray emission and x-ray fluorescence were used. The serum levels of total and free thyroxine (T-4, FT4), and of total, free, and reverse triiodothyronine (T-3, FT3, rT(3), respectively) were assessed by radioimmunoassay. The results were statistically evaluated by one-way analysis of variance and bivariate correlation. The study indicated that the levels of T-4, FT4, and rT(3) increased in the serum of iodine-deficient rats supplemented with I or I + Se. In the same animals, we documented alterations of the content of Br in the brain, and of Zn, Mn, Cu, and Rb in erythrocytes, whereas the brain content of I and Se was unchanged. Thus, I and I + Se supplementation improves thyroid hormone metabolism but affects the content of selected trace elements in erythrocytes and of Br in the brain. The data stimulate further clarification of the role of trace elements in the central nervous system. (C) 2001 Elsevier Science Inc. |
| 学科主题 | Neurosciences & Neurology |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000170112600026 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/236902]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Liu NQ,Xu Q,Hou XL,et al. The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency[J]. BRAIN RESEARCH BULLETIN,2001,55(2):309-312. |
| APA | 刘年庆.,徐清.,侯小琳.,刘平生.,柴之芳.,...&Li, YF.(2001).The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency.BRAIN RESEARCH BULLETIN,55(2),309-312. |
| MLA | 刘年庆,et al."The distribution patterns of trace elements in the brain and erythrocytes in a rat experimental model of iodine deficiency".BRAIN RESEARCH BULLETIN 55.2(2001):309-312. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。