Accumulation of mercury, selenium and their binding proteins in porcine kidney and liver from mercury-exposed areas with the investigation of their redox responses
文献类型：期刊论文
| 作者 | Chen CY(陈春英); Zhao JJ(赵九江); Deng GL(邓桂龙); Li B(李柏) ; Zhang PQ(章佩群); Chai ZF(柴之芳); Chen, CY; Qu, LY; Zhao, JJ; Liu, SP
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| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
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| 出版日期 | 2006 |
| 卷号 | 366期号:2-3页码:627-637 |
| 关键词 | mercury selenium liver kidney metallothionein redox status |
| 通讯作者 | Chinese Acad Sci, Key Lab Nucl Analyt Tech, Beijing 100039, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Beijing 100039, Peoples R China ; Guizhou Res & Designing Inst Environm Sci, Guiyang 550002, Peoples R China ; Wanshan Off Environm Protect, Guizhou, Peoples R China |
| 英文摘要 | The subcellular localization of Se and Hg and their cytosolic binding proteins, including cellular oxidative status, in porcine liver and kidney have been studied by using samples from a chronic Hg-contaminated area and a non-Hg-contaminated area. Coaccumulation and redistribution of Se and Hg in subcellular fractions due to mercury exposure were found. The Hg and Se concentrations in tissues from Hg-exposed porcine were 80 folds and 5-20 folds higher than controls, respectively. Insterestingly, the retention of both Se and Hg increased 10% in mitochondria, while decreased 10% in cytosol of Hg-exposed pig liver. Mercury was mainly in the form of MTs in the cytosol of the non-Hg-exposed porcine kidney. NIT binds Hg in the cytosol with limited capacity, and the rest Hg was redistributed to the high molecular weight (MW) proteins (80-100 kDa) in the Hg-exposed group. The coaccumulation of Hg and Se was also found in high MW proteins, where their molar ratio was tended to be 1: 1. Moreover, the Se-containing polypeptides (3-6 kDa) increased significantly both in hepatic and renal cytosol of the Hg-exposed pigs. Se-dependent GSH-Px and SOD activity were increased to cope with Hg-induced oxidative stress. In previous studies, the roles of Se and MTs were generally taken into account separately; we discussed their combining roles in the case of high Hg exposure. The present results were beneficial to understand the existing states of Hg in vivo and evaluate the interaction of toxic and essential elements. (c) 2006 Elsevier B.V. All rights reserved. |
| 学科主题 | Environmental Sciences & Ecology |
| 类目[WOS] | Environmental Sciences |
| 研究领域[WOS] | Environmental Sciences & Ecology |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000239877400019 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/238143]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_实验物理中心 高能物理研究所_多学科研究中心 中国科学院高能物理研究所_中国散裂中子源 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Chen CY,Zhao JJ,Deng GL,et al. Accumulation of mercury, selenium and their binding proteins in porcine kidney and liver from mercury-exposed areas with the investigation of their redox responses[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2006,366(2-3):627-637. |
| APA | 陈春英.,赵九江.,邓桂龙.,李柏.,章佩群.,...&Chai, ZF.(2006).Accumulation of mercury, selenium and their binding proteins in porcine kidney and liver from mercury-exposed areas with the investigation of their redox responses.SCIENCE OF THE TOTAL ENVIRONMENT,366(2-3),627-637. |
| MLA | 陈春英,et al."Accumulation of mercury, selenium and their binding proteins in porcine kidney and liver from mercury-exposed areas with the investigation of their redox responses".SCIENCE OF THE TOTAL ENVIRONMENT 366.2-3(2006):627-637. |
入库方式： OAI收割
来源：高能物理研究所
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