Correlation of behavior changes and BOLD signal in Alzheimer-like rat model
文献类型：期刊论文
| 作者 | Hu, ZH; Wang, XC; Li, LY; Liu, ML; Liu, R; Ling, ZQ; Tian, Q; Tang, XW ; Wu, YG; Wang, JZ
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| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
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| 出版日期 | 2004 |
| 卷号 | 36期号:12页码:803-810 |
| 关键词 | Alzheimer disease (AD) functional magnetic resonance imaging (fMRI) isoproterenol (IP) Morris Water Maze diagnosis |
| 通讯作者 | Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pathophysiol, Wuhan 430030, Peoples R China ; Zhejiang Univ, Dept Phys, Hangzhou 310027, Peoples R China ; Zhejiang Univ, BioX Disciplinary Lab, Hangzhou 310027, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Beijing 100039, Peoples R China ; Chinese Acad Sci, Key Lab Nucl Anal Tech, Beijing 100039, Peoples R China ; Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 英文摘要 | To explore a potential means for the early diagnosis of Alzheimer disease, we studied the relationship of resting T2* signal and tau hyperphosphorylation/spatial memory deficit. The rat model with tau hyperphosphorylation and spatial memory deficit was established by bilateral hippocampi injection of isoproterenol (IP). Then, the correlative alteration between resting T2* signal and spatial memory retention was assessed with blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) study and Morris Water Maze test, and Western blot was employed to confirm tau hyperphosphorylation. The analysis showed following results. (1) Tau phosphorylation at Ser(396)/Ser(404) and Ser(199)/Ser(202) was significantly increased in IP-injected rats as detected by PHF-1 and tau-1, respectively. (2) An AD-like spatial memory retention disturbance was induced at 24 h after isoproterenol injection. (3) A sensitivity threshold of resting T2* signal intensity, which separated the IP-treated rats from vehicle control, was obtained by applying linear regression analysis, and an estimated sensitivity statistical threshold was at 32.62. These results suggest that resting T2* signal may serve as a noninvasive quantitative marker in predicting AD-like spatial memory deficits and tau hyperphosphorylation. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000225986000004 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/238522]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_粒子天体物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Hu, ZH,Wang, XC,Li, LY,et al. Correlation of behavior changes and BOLD signal in Alzheimer-like rat model[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2004,36(12):803-810. |
| APA | Hu, ZH.,Wang, XC.,Li, LY.,Liu, ML.,Liu, R.,...&吴义根.(2004).Correlation of behavior changes and BOLD signal in Alzheimer-like rat model.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,36(12),803-810. |
| MLA | Hu, ZH,et al."Correlation of behavior changes and BOLD signal in Alzheimer-like rat model".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 36.12(2004):803-810. |
入库方式： OAI收割
来源：高能物理研究所
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