Mapping technique for biodistribution of elements in a model organism, Caenorhabditis elegans, after exposure to copper nanoparticles with microbeam synchrotron radiation X-ray fluorescence
文献类型：期刊论文
| 作者 | Gao YX(高愈希) ; Liu NQ(刘年庆); Chen CY(陈春英); Li YF(李玉锋); Zhang ZY(张智勇); Zhao YL(赵宇亮); Chai ZF(柴之芳); Gao, Y; Liu, NQ; Chen, CY
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| 刊名 | JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
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| 出版日期 | 2008 |
| 卷号 | 23期号:8页码:1121-1124 |
| 通讯作者 | [Gao, Yuxi ; Liu, Nianqing ; Chen, Chunying ; Li, Yufeng ; Zhang, Zhiyong ; Zhao, Yuliang ; Chai, Zhifang] Chinese Acad Sci, Bioenvironm Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Gao, Yuxi ; Liu, Nianqing ; Chen, Chunying ; Li, Yufeng ; Zhang, Zhiyong ; Zhao, Yuliang ; Chai, Zhifang] Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Beijing 100049, Peoples R China ; [Luo, Yunfeng] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China ; [Chen, Chunying] Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China ; [Iida, Atsuo] High Energy Accelerator Res Org, Photon Factory, Inst Mat Struct Sci, Tsukuba, Ibaraki 3050801, Japan |
| 英文摘要 | To investigate the toxicological effects of nanomaterials, experimental studies on the absorption and accumulation in organisms are of broad interest. In the present study, Caenorhabditis elegans (C. elegans) was used as a "model'' organism to investigate the bioaccumulation and toxicological effects of engineered copper nanoparticles with a scanning technique of microbeam synchrotron radiation X-ray fluorescence (m-SRXRF). The adult hermaphrodite is anatomically simple with 959 somatic cells and 1 mm in length. The mapping results of the whole organism indicate that the exposure to copper nanoparticles can result in an obvious elevation of Cu and K levels, and a change of bio-distribution of Cu in nematodes. Accumulation of Cu occurs in the head and at a location 1/3 of the way up the body from the tail compared to the un- exposed control. In contrast, a higher amount of Cu was detected in other portion of worm body, especially in its excretory cells and intestine when exposed to Cu(2+). The results compared well with total Cu levels in nematodes, which were 4.10 +/- 0.54, 12.32 +/- 0.49 and 5.22 +/- 0.63 mu g g(-1) dry weight for the PBS, Cu(2+) and Cu nanoparticle groups, respectively, measured by ICP- MS. The nondestructive and multi- elemental m- SRXRF provides an important tool for mapping the elemental distribution in the whole body of a single tiny nematode at lower levels. |
| 学科主题 | Chemistry; Spectroscopy |
| 类目[WOS] | Chemistry, Analytical ; Spectroscopy |
| 研究领域[WOS] | Chemistry ; Spectroscopy |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000257982600012 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/239081]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_加速器中心 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Gao YX,Liu NQ,Chen CY,et al. Mapping technique for biodistribution of elements in a model organism, Caenorhabditis elegans, after exposure to copper nanoparticles with microbeam synchrotron radiation X-ray fluorescence[J]. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,2008,23(8):1121-1124. |
| APA | 高愈希.,刘年庆.,陈春英.,李玉锋.,张智勇.,...&Chai, ZF.(2008).Mapping technique for biodistribution of elements in a model organism, Caenorhabditis elegans, after exposure to copper nanoparticles with microbeam synchrotron radiation X-ray fluorescence.JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,23(8),1121-1124. |
| MLA | 高愈希,et al."Mapping technique for biodistribution of elements in a model organism, Caenorhabditis elegans, after exposure to copper nanoparticles with microbeam synchrotron radiation X-ray fluorescence".JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY 23.8(2008):1121-1124. |
入库方式： OAI收割
来源：高能物理研究所
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