The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts
文献类型：期刊论文
| 作者 | Yang N(杨宁); Chen ZC(陈忠才); Tang XW(唐孝威) ; Yang, N; Chen, ZC; Lu, P; Zhang, CM; Zhai, ZH; Tang, XW
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| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2003 |
| 卷号 | 48期号:18页码:1912-1918 |
| 关键词 | nuclear reassembly microtubule colchicine taxol Xenopus egg extracts |
| 通讯作者 | Peking Univ, Dept Cell Biol & Genet, Beijing 100871, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Beijing 100039, Peoples R China ; Peking Univ, Coll Life Sci, Natl Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China |
| 英文摘要 | Nuclear envelope is a dynamic structure in the cell cycle. At the beginning of mitosis, nuclear envelope breaks down and its components disperse into the cytoplasm. At the end of mitosis, nuclear envelope reassembles using the dispersed components. Searching for the mechanisms of the nuclear disassembly and reassembly has for a long time been one of the key projects for cell biologists. In this report we show that microtubules take a role in the nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts. Microtubule cytoskeleton has been demonstrated to take roles in the transport of intracellular membranes such as Golgi and ER vesicles. We found that the nuclear envelope assembly needs functional microtubules. At the beginning of the nuclear assembly, microtubules nucleated to form a microtubule aster around the centrosome at the base of the sperm head. Using the microtubule drug colchicine to disrupt the microtubule nucleation, nuclear envelope reassembly was seriously inhibited. If the microtubules were stabilized by taxol, another microtubule drug, the nuclear envelope reassembly was also interfered, although a significantly large aster formed around the chromatin. Based on these observations, we propose that microtubules play an important role in the nuclear envelope reassembly maybe by transporting the nuclear envelope precursors to the chromatin surfaces. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000185748100003 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/239577]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_粒子天体物理中心 中国科学院高能物理研究所_中国散裂中子源 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Yang N,Chen ZC,Tang XW,et al. The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts[J]. CHINESE SCIENCE BULLETIN,2003,48(18):1912-1918. |
| APA | 杨宁.,陈忠才.,唐孝威.,Yang, N.,Chen, ZC.,...&Tang, XW.(2003).The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts.CHINESE SCIENCE BULLETIN,48(18),1912-1918. |
| MLA | 杨宁,et al."The microtubule aster formation and its role in nuclear envelope assembly around the sperm chromatin in Xenopus egg extracts".CHINESE SCIENCE BULLETIN 48.18(2003):1912-1918. |
入库方式： OAI收割
来源：高能物理研究所
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