Multi hydroxylated [Gd@C-82(OH)(22)](n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity
文献类型：期刊论文
| 作者 | Chen CY(陈春英); Xing GM(邢更妹) ; Wang JX(王江雪); Zhao YL(赵宇亮); Li B(李柏); Sun J(孙进); Yuan H(袁慧); Gao YX(高义贤); Meng H(孟浩); Chen Z(陈真)
|
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2005 |
| 卷号 | 5期号:10页码:2050-2057 |
| 通讯作者 | Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Techniques, Beijing 100049, Peoples R China ; Peking Univ, Hosp 3, Dept Clin Lab, Sch Publ Hlth, Beijing 100083, Peoples R China ; Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China ; Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 英文摘要 | [Gd@C-82(OH)(22)](n) particles (22 nm in a saline solution) of a dose level as low as 10(-7) mol/kg exhibit a very high antineoplastic efficiency (similar to 60%) in mice. A dose increment of 1 x 10(-7) mol/kg increases the tumor inhibition rate 26%. [Gd@C-82(OH)(22)](n) particles have a strong capacity to improve immunity and interfere with tumor invasion in normal muscle cells, nearly without toxicity in vivo and in vitro. Unlike conventional antineoplastic chemicals, the high antitumor efficiency of nanoparticles is not due to toxic effects to cells because they do not kill the tumor cells directly and only about 0.05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000232623700038 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/239633]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_实验物理中心 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Chen CY,Xing GM,Wang JX,et al. Multi hydroxylated [Gd@C-82(OH)(22)](n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity[J]. NANO LETTERS,2005,5(10):2050-2057. |
| APA | 陈春英.,邢更妹.,王江雪.,赵宇亮.,李柏.,...&Fang, XH.(2005).Multi hydroxylated [Gd@C-82(OH)(22)](n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity.NANO LETTERS,5(10),2050-2057. |
| MLA | 陈春英,et al."Multi hydroxylated [Gd@C-82(OH)(22)](n) nanoparticles: Antineoplastic activity of high efficiency and low toxicity".NANO LETTERS 5.10(2005):2050-2057. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。