Distribution of metalloproteins in hepatocellular carcinoma and surrounding tissues
文献类型：期刊论文
| 作者 | Liu, YB ; Li LN(李丽娜); Gao YX(高愈希); Chen CY(陈春英); Li B(李柏); He W(何伟); Huang YY(黄宇营); Chai ZF(柴之芳); Li, LN; Gao, YX
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| 刊名 | HEPATO-GASTROENTEROLOGY
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| 出版日期 | 2007 |
| 卷号 | 54期号:80页码:2291-2296 |
| 关键词 | hepatocellular carcinoma metalloproteins microsome cytosol synchrotron radiation X-ray fluorescence isoelectric focusing |
| 通讯作者 | [Li, Lina ; Gao, Yuxi ; Chen, Chunying ; Li, Bai ; He, Wei ; Huang, Yuying ; Chai, Zhifang] Chinese Acad Sci, Multidisciplinary Res Ctr, Inst High Energy Phys, Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Li, Lina ; Gao, Yuxi ; Chen, Chunying ; Li, Bai ; He, Wei ; Huang, Yuying ; Chai, Zhifang] Chinese Acad Sci, Multidisciplinary Res Ctr, Inst High Energy Phys, Lab Biol Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Liu, Yingbin] Zhejiang Univ, Affiliated Hosp 2, Dept Surg, Hangzhou 310027, Peoples R China ; [Li, Lina] Baotou Med Coll, Dept Basic Med, Baotou, Peoples R China |
| 英文摘要 | Background/Aims: The aim of this study was to investigate the relationship between metalloproteins distributions and cancer development in human liver tissues. Methodology: Proteins in the cytosol and microsome of tumor and surrounding nontumor tissues from five individuals with HCC were separated with isoelectric focusing. Zinc, iron, copper, and manganese contents in protein bands were measured with synchrotron radiation X-ray fluorescence. Results: In the cytosol, the metal contents in protein bands from tumor tissues were generally less than those from corresponding nontumor tissues, especially in the Fe-containing bands with isoelectric points of 6.5 and 8.0, and Cu, Zn-containing band of 5.5. However, reversed metal contents in Fe, Cu-containing band of 4.0 and Zn-containing bands of 3.9 and 4.3 were observed. In microsomes, the metal contents of protein bands were generally similar between tumor and nontumor tissues, but the Fe content in tumor tissues was 2.5-fold lower in the band of 5.9, the Cu and Zn contents were 2 and 3.5-fold higher in the band of 9.3, respectively, compared to that of nontumor tissues. Conclusions: Metal distributions among the detected metal-containing bands are distinguishable between tumor and nontumor tissues. The difference of the distribution may be involved in the carcinogenesis of the liver tissues. |
| 学科主题 | Gastroenterology & Hepatology; Surgery |
| 类目[WOS] | Gastroenterology & Hepatology ; Surgery |
| 研究领域[WOS] | Gastroenterology & Hepatology ; Surgery |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000251892800024 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/239711]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_实验物理中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Liu, YB,Li LN,Gao YX,et al. Distribution of metalloproteins in hepatocellular carcinoma and surrounding tissues[J]. HEPATO-GASTROENTEROLOGY,2007,54(80):2291-2296. |
| APA | Liu, YB.,李丽娜.,高愈希.,陈春英.,李柏.,...&Chai, ZF.(2007).Distribution of metalloproteins in hepatocellular carcinoma and surrounding tissues.HEPATO-GASTROENTEROLOGY,54(80),2291-2296. |
| MLA | Liu, YB,et al."Distribution of metalloproteins in hepatocellular carcinoma and surrounding tissues".HEPATO-GASTROENTEROLOGY 54.80(2007):2291-2296. |
入库方式： OAI收割
来源：高能物理研究所
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