Oxidative Stress and Apoptosis Induced by Iron Oxide Nanoparticles in Cultured Human Umbilical Endothelial Cells
文献类型：期刊论文
| 作者 | Zhu MT(朱墨桃); Wang Y(王云) ; Feng WY(丰伟悦); Wang B(汪冰); Wang M(王萌); Ou YH(欧阳宏); Chai ZF(柴之芳); Zhu, MT; Yun, W; Feng, WY
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| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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| 出版日期 | 2010 |
| 卷号 | 10期号:12页码:8584-8590 |
| 关键词 | Iron Oxide Nanoparticle Oxidative Stress Apoptosis Human Umbilical Endothelial Cells |
| 通讯作者 | [Zhu, Mo-Tao ; Yun Wang ; Feng, Wei-Yue ; Bing Wang ; Meng Wang ; Hong Ouyang ; Chai, Zhi-Fang] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Zhu, Mo-Tao ; Yun Wang] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 英文摘要 | Recent epidemiologic researches indicate that exposure to ultrafine particles (nanoparticles) is an independent risk factor for several cardiovascular diseases. The induction of endothelial injuries is hypothesized to be an attractive mechanism involved in these cardiovascular diseases. To investigate this hypothesis, the widely used iron nanomaterials, ferric oxide (Fe(2)O(3)) and ferriferrous oxide (Fe(3)O(4)) nanoparticles were incubated with human umbilical endothelial cells (ECV304 cells) at different concentrations of 2, 20, 100 mu g/mL. The cell viability, the rate of apoptosis, the apoptotic nuclear morphology and the mitochondria membrane potential were measured to estimate the cell necrosis and apoptosis caused by the nanoparticle exposure. The stimulation of superoxide anion (O(2).(-)) and nitric oxide (NO) were examined to evaluate the stress responses of endothelial cells. Our results indicated that both the Fe(2)O(3) and Fe(3)O(4) nanoparticles could generate oxidative stress as well as the significant increase of nitric oxide in ECV304 cells. The loss of mitochondria membrane potential and the apoptotic chromatin condensation in the nucleus were observed as the early signs of apoptosis. It is inferred the stress response might be an important mechanism involving in endothelial cells apoptosis and death, and these injuries in endothelial cells might play a key role in downstream cardiovascular diseases such as atheroscelerosis, hypertension and myocardial infarction (MI). |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 类目[WOS] | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000283621400096 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/240143]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_加速器中心 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhu MT,Wang Y,Feng WY,et al. Oxidative Stress and Apoptosis Induced by Iron Oxide Nanoparticles in Cultured Human Umbilical Endothelial Cells[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(12):8584-8590. |
| APA | 朱墨桃.,王云.,丰伟悦.,汪冰.,王萌.,...&Chai, ZF.(2010).Oxidative Stress and Apoptosis Induced by Iron Oxide Nanoparticles in Cultured Human Umbilical Endothelial Cells.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(12),8584-8590. |
| MLA | 朱墨桃,et al."Oxidative Stress and Apoptosis Induced by Iron Oxide Nanoparticles in Cultured Human Umbilical Endothelial Cells".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.12(2010):8584-8590. |
入库方式： OAI收割
来源：高能物理研究所
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