Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO(2) Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population
文献类型：期刊论文
| 作者 | Chen Z(陈真); Meng H(孟幻); Xing GM(邢更妹) ; Yuan H(袁慧); Zhao F(赵峰); Liu R(刘茹); Chang XL(常雪灵); Gao XY(高学云); Ye C(叶昶); Chai ZF(柴之芳)
|
| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2008 |
| 卷号 | 42期号:23页码:8985-8992 |
| 通讯作者 | [Chen, Zhen ; Meng, Huan ; Xing, Gengmei ; Yuan, Hui ; Zhao, Feng ; Liu, Ru ; Chang, Xuelin ; Gao, Xueyun ; Ye, Chang ; Chai, Zhifang ; Zhao, Yuliang] Chinese Acad Sci, Lab Bioenvironm Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Chen, Zhen ; Meng, Huan ; Xing, Gengmei ; Yuan, Hui ; Zhao, Feng ; Liu, Ru ; Chang, Xuelin ; Gao, Xueyun ; Ye, Chang ; Chai, Zhifang ; Zhao, Yuliang] Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China ; [Jia, Guang] Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China ; [Wang, Tiancheng] Peking Univ, Hosp 3, Beijing 100083, Peoples R China ; [Chen, Zhen ; Meng, Huan ; Liu, Ru ; Gao, Xueyun ; Zhao, Yuliang] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 英文摘要 | Epidemiologic studies have revealed that pollution by ambient particulates is associated with respiratory and cardiovascular diseases, particularly in older people. Toxicologic sensitivity of nanoparticles in different ages was investigated for the first time to demonstrate and explain an age-related difference in response to manufactured nanoparticles. Young, adult, and old rats physiologically inhaled air containing aerosol of manufactured SiO(2) nanoparticles (24.1 mg/m(3); 40 min/day) for four weeks. Changes in serum biomarkers, hemorheologic, pulmonary inflammation, heart injury, and pathology in rats of different ages and their corresponding controls were compared. Inhalation of SiO(2) nanoparticles under identical conditions caused pulmonary and cardiovascular alterations in old rats, yet less change in young and adult rats, including pulmonary inflammation, myocardial ischernic damage, atrio-ventricular blockage, and increase in fibrinogen concentration and blood viscosity. Old individuals were more sensitive to nanoparticle exposure than the young and adult rats. The risk of causing pulmonary damages was: old > young > adult. The risk of cardiovascular disorder was observed only in old age. Our results suggest that different ages may require different biomarkers for identifying pulmonary toxicity during inhalation of nanoparticles. |
| 学科主题 | Engineering; Environmental Sciences & Ecology |
| 类目[WOS] | Engineering, Environmental ; Environmental Sciences |
| 研究领域[WOS] | Engineering ; Environmental Sciences & Ecology |
| 原文出处 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000261307200063 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/240154]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Chen Z,Meng H,Xing GM,et al. Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO(2) Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2008,42(23):8985-8992. |
| APA | 陈真.,孟幻.,邢更妹.,袁慧.,赵峰.,...&Zhao, YL.(2008).Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO(2) Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population.ENVIRONMENTAL SCIENCE & TECHNOLOGY,42(23),8985-8992. |
| MLA | 陈真,et al."Age-Related Differences in Pulmonary and Cardiovascular Responses to SiO(2) Nanoparticle Inhalation: Nanotoxicity Has Susceptible Population".ENVIRONMENTAL SCIENCE & TECHNOLOGY 42.23(2008):8985-8992. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。