Immunostimulatory properties and enhanced TNF-alpha mediated cellular immunity for tumor therapy by C-60(OH)(20) nanoparticles
文献类型:期刊论文
作者 | Liu, Y; Jiao, F; Qiu, Y; Li, W; Qu, Y; Tian, CX; Li, YF; Bai, R; Lao, F; Zhao, YL |
刊名 | NANOTECHNOLOGY |
出版日期 | 2009 |
卷号 | 20期号:41页码:415102 |
通讯作者 | [Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China ; [Chen, Chunying] Natl Ctr Nanosci & Technol China, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China |
英文摘要 | Publications concerning the mechanism of biological activity, especially the immunological mechanism of C-60(OH)(20) nanoparticles, are relatively limited. However, the structure and characteristics of this carbon allotrope have been widely investigated. In this paper, we have demonstrated that water-soluble C-60(OH)(20) nanoparticles have an efficient anti-tumor activity in vivo, and show specific immunomodulatory effects to the immune cells, such as T cells and macrophages, both in vivo and in vitro. For example, C-60(OH)(20) nanoparticles can increase the production of T-helper cell type 1 (Th1) cytokines (IL-2, IFN-gamma and TNF-alpha), and decrease the production of Th2 cytokines (IL-4, IL-5 and IL-6) in serum samples. On the other hand, C-60(OH)(20) nanoparticles show almost no adverse effect to the viability of immune cells in vitro but stimulate the immune cells to release more cytokines, in particular TNF-alpha, which plays a key role in the cellular immune process to help eliminate abnormal cells. TNF-alpha production increased almost three-fold in treated T lymphocytes and macrophages. Accordingly, we conclude that C-60(OH)(20) nanoparticles have an efficient anti-tumor activity and this effect is associated with an increased CD4+/CD8+ lymphocyte ratio and the enhancement of TNF-alpha production. The data suggest that C-60(OH)(20) nanoparticles can improve the immune response to help to scavenge and kill tumor cells. |
学科主题 | Science & Technology - Other Topics; Materials Science; Physics |
类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
研究领域[WOS] | Science & Technology - Other Topics ; Materials Science ; Physics |
原文出处 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000269930100003 |
源URL | [http://ir.ihep.ac.cn/handle/311005/241061] |
专题 | 高能物理研究所_院士 |
作者单位 | 中国科学院高能物理研究所 |
推荐引用方式 GB/T 7714 | Liu, Y,Jiao, F,Qiu, Y,et al. Immunostimulatory properties and enhanced TNF-alpha mediated cellular immunity for tumor therapy by C-60(OH)(20) nanoparticles[J]. NANOTECHNOLOGY,2009,20(41):415102. |
APA | Liu, Y.,Jiao, F.,Qiu, Y.,Li, W.,Qu, Y.,...&柴之芳.(2009).Immunostimulatory properties and enhanced TNF-alpha mediated cellular immunity for tumor therapy by C-60(OH)(20) nanoparticles.NANOTECHNOLOGY,20(41),415102. |
MLA | Liu, Y,et al."Immunostimulatory properties and enhanced TNF-alpha mediated cellular immunity for tumor therapy by C-60(OH)(20) nanoparticles".NANOTECHNOLOGY 20.41(2009):415102. |
入库方式: OAI收割
来源:高能物理研究所
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