The Left Fusiform Gyrus is a Critical Region Contributing to the Core Behavioral Profile of Semantic Dementia
文献类型：期刊论文
| 作者 | Ding, Junhua1; Chen, Keliang2; Chen, Yan1 ; Fang, Yuxing1; Yang, Qing2; Lv, Yingru3; Lin, Nan4; Bi, Yanchao1; Guo, Qihao2; Han, Zaizhu1
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| 刊名 | FRONTIERS IN HUMAN NEUROSCIENCE
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| 出版日期 | 2016-05-19 |
| 卷号 | 10期号:0页码:215 |
| 关键词 | lesion-behavior mapping fusiform gyrus co-atrophy semantic dementia semantic deficits |
| ISSN号 | 1662-5161 |
| 英文摘要 | Given that extensive cerebral regions are co-atrophic in semantic dementia (SD), it is not yet known which critical regions (SD-semantic-critical regions) are really responsible for the semantic deficits of SD. To identify the SD-semantic-critical regions, we explored the relationship between the degree of cerebral atrophy in the whole brain and the severity of semantic deficits in 19 individuals with SD. We found that the gray matter volumes (GMVs) of two regions [left fusiform gyrus (IFFG) and left parahippocampal gyrus (IPHG)] significantly correlated with the semantic scores of patients with SD. Importantly, the effects of the IFFG remained significant after controlling for the GMVs of the IPHG. Moreover, the effects of the region could not be accounted for by the total GMV, general cognitive ability, laterality of brain atrophy, or control task performance. We further observed that each atrophic portion of the IFFG along the anterior posterior axis might dedicate to the loss of semantic functions in SD. These results reveal that the IFFG could be a critical region contributing to the semantic deficits of SD. |
| WOS标题词 | Science & Technology ; Social Sciences ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Psychology |
| 研究领域[WOS] | Neurosciences & Neurology ; Psychology |
| 关键词[WOS] | PRIMARY PROGRESSIVE APHASIA ; DISTORTION-CORRECTED FMRI ; ANTERIOR TEMPORAL-LOBES ; HUMAN BRAIN ; ALZHEIMERS-DISEASE ; PERIRHINAL CORTEX ; PATTERNS ; ATROPHY ; CHINESE ; REPRESENTATION |
| 收录类别 | SCI ; SSCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000376059700001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/19994]  |
| 专题 | 心理研究所_认知与发展心理学研究室 |
| 作者单位 | 1.Beijing Normal Univ, IDG McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 2.Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai 200433, Peoples R China 3.Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai 200433, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Junhua,Chen, Keliang,Chen, Yan,et al. The Left Fusiform Gyrus is a Critical Region Contributing to the Core Behavioral Profile of Semantic Dementia[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2016,10(0):215. |
| APA | Ding, Junhua.,Chen, Keliang.,Chen, Yan.,Fang, Yuxing.,Yang, Qing.,...&Han, Zaizhu.(2016).The Left Fusiform Gyrus is a Critical Region Contributing to the Core Behavioral Profile of Semantic Dementia.FRONTIERS IN HUMAN NEUROSCIENCE,10(0),215. |
| MLA | Ding, Junhua,et al."The Left Fusiform Gyrus is a Critical Region Contributing to the Core Behavioral Profile of Semantic Dementia".FRONTIERS IN HUMAN NEUROSCIENCE 10.0(2016):215. |
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来源：心理研究所
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