Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocin
文献类型：期刊论文
| 作者 | Meng, Xiaolu1,2 ; Shen, Fang1; Li, Chunlu1,2; Li, Yonghui1; Wang, Xuewei3
|
| 刊名 | PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 145期号:0页码:1-8 |
| 关键词 | Depression-like behaviors Tree shrews Uncontrollable foot shocks Chronic unpredictable stress Carbetocin |
| ISSN号 | 0091-3057 |
| 英文摘要 | Tree shrews, a species phylogenetically close to primates, are regarded as a suitable and naturalistic animal model for depression studies. However, psychological symptoms that are essential for depression diagnosis and treatment, such as helplessness and social withdrawal, have not been studied in this model. Therefore, in this study, we first investigated learned helplessness, social interaction and sucrose preference induced by two chronic stress paradigms: uncontrollable foot shocks (1-week foot shocks) and multiple unpredictable stimuli (1-week foot shocks and 3-week unpredictable stressors) in tree shrews. Our results showed that uncontrollable foot shocks could only induce learned helplessness in animals; whereas animals treated with multiple unpredictable stimuli exhibited more depression-like behaviors including social withdrawal, anhedonia and learned helplessness. These findings suggested that multiple unpredictable stimuli could effectively induce various depression-like behaviors in tree shrews. More importantly, we compared the antidepressant effects of fluoxetine and carbetocin, a long-acting oxytocin analog, on specific depression-like behaviors. Our present data displayed that, compared with fluoxetine, carbetocin was also effective in reversing learned helplessness, elevating sucrose preference and improving social interaction behaviors in depression-like animals. Therefore, carbetocin might be a potential antidepressant with applications in humans. (C) 2016 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 关键词[WOS] | CHRONIC PSYCHOSOCIAL STRESS ; LEARNED HELPLESSNESS ; TUPAIA-BELANGERI ; MAJOR DEPRESSION ; SEXUAL-BEHAVIOR ; BRAIN OXYTOCIN ; MALE-RATS ; ANTIDEPRESSANT ; SYSTEM ; VASOPRESSIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000377326300001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/19950]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lin Cui Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 3.Johns Hopkins Univ, Sch Med, Dept Orthoped Surg, Baltimore, MD USA |
| 推荐引用方式 GB/T 7714 | Meng, Xiaolu,Shen, Fang,Li, Chunlu,et al. Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocin[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2016,145(0):1-8. |
| APA | Meng, Xiaolu,Shen, Fang,Li, Chunlu,Li, Yonghui,&Wang, Xuewei.(2016).Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocin.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,145(0),1-8. |
| MLA | Meng, Xiaolu,et al."Depression-like behaviors in tree shrews and comparison of the effects of treatment with fluoxetine and carbetocin".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 145.0(2016):1-8. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。