Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats
文献类型：期刊论文
| 作者 | Zhang, Jian-Jun1,2,3 ; Liu, Xiao-Dong2,3; Yu, Long-Chuan2,3
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| 刊名 | PHYSIOLOGICAL RESEARCH
 |
| 出版日期 | 2016 |
| 卷号 | 65期号:1页码:165-169 |
| 关键词 | Discharge frequency Excitatory synaptic transmission Evoked excitatory postsynaptic currents (eEPSCs) Lateral amygdala Morphine Spontaneous excitatory postsynaptic currents (sEPSCs) |
| ISSN号 | 0862-8408 |
| 英文摘要 | Acute morphine exposure induces antinociceptive activity, but the underlying mechanisms in the central nervous system are unclear. Using whole-cell patch clamp recordings, we explore the role of morphine in the modulation of excitatory synaptic transmission in lateral amygdala neurons of rats. The results demonstrate that perfusion of 10 mu M of morphine to the lateral amygdala inhibits the discharge frequency significantly. We further find that there are no significant influences of morphine on the amplitude of spontaneous excitatory postsynaptic currents (sEPSCs). Interestingly, morphine shows no marked influence on the evoked excitatory postsynaptic currents (eEPSCs) in the lateral amygdala neurons. These results indicate that acute morphine treatment plays an important role in the modulation on the excitatory synaptic transmission in lateral amygdala neurons of rats. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Physiology |
| 研究领域[WOS] | Physiology |
| 关键词[WOS] | TAIL-FLICK REFLEX ; CENTRAL NUCLEUS ; BASOLATERAL AMYGDALA ; RECEPTOR SUBUNIT ; CORTEX ; ANTINOCICEPTION ; MICROINJECTION ; CONTRIBUTES ; INHIBITION ; WITHDRAWAL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000377529800017 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/19953]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Peking Univ, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China 3.Peking Univ, Neurobiol Lab, Coll Life Sci, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jian-Jun,Liu, Xiao-Dong,Yu, Long-Chuan. Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats[J]. PHYSIOLOGICAL RESEARCH,2016,65(1):165-169. |
| APA | Zhang, Jian-Jun,Liu, Xiao-Dong,&Yu, Long-Chuan.(2016).Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats.PHYSIOLOGICAL RESEARCH,65(1),165-169. |
| MLA | Zhang, Jian-Jun,et al."Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats".PHYSIOLOGICAL RESEARCH 65.1(2016):165-169. |
入库方式： OAI收割
来源：心理研究所
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