Shielding of the Geomagnetic Field Alters Actin Assembly and Inhibits Cell Motility in Human Neuroblastoma Cells
文献类型：期刊论文
| 作者 | Mo, Wei-Chuan1,2; Zhang, Zi-Jian1,3 ; Wang, Dong-Liang1; Liu, Ying1; Bartlett, Perry F.2; He, Rong-Qiao1,4,5
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-03-31 |
| 卷号 | 6期号:0页码:1-15 |
| ISSN号 | 2045-2322 |
| 英文摘要 | Accumulating evidence has shown that absence of the geomagnetic field (GMF), the so-called hypomagnetic field (HMF) environment, alters the biological functions in seemingly nonmagnetosensitive cells and organisms, which indicates that the GMF could be sensed by non-ironrich and non-photo-sensing cells. The underlying mechanisms of the HMF effects on those cells are closely related to their GMF sensation but remain poorly understood so far. Previously, we found that the HMF represses expressions of genes associated with cell migration and cytoskeleton assembly in human neuroblastoma cells (SH-SY5Y cell line). Here, we measured the HMF-induced changes on cell morphology, adhesion, motility and actin cytoskeleton in SH-SY5Y cells. The HMF inhibited cell adhesion and migration accompanied with a reduction in cellular F-actin amount. Moreover, following exposure to the HMF, the number of cell processes was reduced and cells were smaller in size and more round in shape. Furthermore, disordered kinetics of actin assembly in vitro were observed during exposure to the HMF, as evidenced by the presence of granule and meshed products. These results indicate that elimination of the GMF affects assembly of the motility-related actin cytoskeleton, and suggest that F-actin is a target of HMF exposure and probably a mediator of GMF sensation. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | ZERO MAGNETIC-FIELD ; HYPOMAGNETIC FIELD ; F-ACTIN ; HYPOGEOMAGNETIC FIELD ; IN-VITRO ; ADHESION ; MIGRATION ; GROWTH ; MICE ; MAGNETORECEPTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000373069500001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/19956]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 3.Beijing Univ Chinese Med, Beijing 100029, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 5.Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing 10069, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mo, Wei-Chuan,Zhang, Zi-Jian,Wang, Dong-Liang,et al. Shielding of the Geomagnetic Field Alters Actin Assembly and Inhibits Cell Motility in Human Neuroblastoma Cells[J]. SCIENTIFIC REPORTS,2016,6(0):1-15. |
| APA | Mo, Wei-Chuan,Zhang, Zi-Jian,Wang, Dong-Liang,Liu, Ying,Bartlett, Perry F.,&He, Rong-Qiao.(2016).Shielding of the Geomagnetic Field Alters Actin Assembly and Inhibits Cell Motility in Human Neuroblastoma Cells.SCIENTIFIC REPORTS,6(0),1-15. |
| MLA | Mo, Wei-Chuan,et al."Shielding of the Geomagnetic Field Alters Actin Assembly and Inhibits Cell Motility in Human Neuroblastoma Cells".SCIENTIFIC REPORTS 6.0(2016):1-15. |
入库方式： OAI收割
来源：心理研究所
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