Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats
文献类型：期刊论文
| 作者 | Lu, Jun1; Shao, Run-Hui1; Hu, Li2 ; Tu, Ya1; Guo, Jian-You3
|
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2016-04-08 |
| 卷号 | 618期号:0页码:31-38 |
| 关键词 | Chronic stress Depression Acupuncture Pro-inflammatory cytokines |
| ISSN号 | 0304-3940 |
| 英文摘要 | Accumulating evidence indicates that inflammation may contribute to the pathophysiology of depression. Acupuncture in traditional Chinese medicine has been considered an effective treatment for depression. However, whether the mechanisms that underlie the antidepressant effect of acupuncture are related to its antiinflammatory properties remains unclear. In the present study, rats were exposed to chronic unpredictable mild stress (CUMS) for 28 days to induce depressive-like behavior. Body weight, sucrose preference, and locomotor activity in the open field were measured. After the behavioral tests, reverse transcription polymerase chain reaction was used to determine the mRNA expression of proinflammatory cytokines (interleukin-1 beta [IL-1 beta], interleukin-6 [IL-6], and tumor necrosis factor-alpha [TNF-alpha]), and enzyme-linked immunosorbent assay was used to detect cytokine concentrations. CUMS rats exhibited decrease in body weight, sucrose preference, and locomotor activity in the open field test. Chronic acupuncture and fluoxetine treatment reversed CUMS-induced depressive-like behavior. Compared with control rats, the mRNA and protein expression of IL-1 beta, IL-6, and TNF-alpha in the hippocampus and prefrontal cortex and cytokine concentrations in serum significantly increased in CUMS rats. Acupuncture and fluoxetine treatment significantly decreased the levels of proinflammatory cytokines in the hippocampus, prefrontal cortex, and serum. These results suggest that acupuncture has antidepressant-like effects, and its mechanism of action appears to involve the inhibition of proinflammatory cytokines. (C) 2016 Elsevier Ireland Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | NECROSIS-FACTOR-ALPHA ; CHRONIC MILD STRESS ; CHRONIC UNPREDICTABLE STRESS ; PERIPHERAL IMMUNE CHALLENGE ; PROINFLAMMATORY CYTOKINES ; MAJOR DEPRESSION ; BRAIN ; EXPRESSION ; DISORDER ; INFLAMMATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000374610100006 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/19972]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Beijing Univ Chinese Med, Coll Acupuncture Moxibust & Tui Na, Beijing 100029, Peoples R China 2.Tangshan Feng Run Hosp TCM, Tangshan 064000, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Jun,Shao, Run-Hui,Hu, Li,et al. Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats[J]. NEUROSCIENCE LETTERS,2016,618(0):31-38. |
| APA | Lu, Jun,Shao, Run-Hui,Hu, Li,Tu, Ya,&Guo, Jian-You.(2016).Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats.NEUROSCIENCE LETTERS,618(0),31-38. |
| MLA | Lu, Jun,et al."Potential antiinflammatory effects of acupuncture in a chronic stress model of depression in rats".NEUROSCIENCE LETTERS 618.0(2016):31-38. |
入库方式： OAI收割
来源：心理研究所
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